Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 18,000 | |||
2 mg | 在庫あり | ¥ 26,000 | |||
5 mg | 在庫あり | ¥ 42,000 | |||
10 mg | 在庫あり | ¥ 71,500 | |||
25 mg | 在庫あり | ¥ 120,000 | |||
50 mg | 在庫あり | ¥ 174,500 | |||
100 mg | 在庫あり | ¥ 243,500 |
説明 | BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1]. |
In vitro | NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3]. |
分子量 | 423.5 |
分子式 | C24H29N3O4 |
CAS No. | 1909226-00-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (11.8 mM)
DMSO: 78 mg/mL (184.2 mM)
You can also refer to dose conversion for different animals. 詳細
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BDA-366 1909226-00-1 Apoptosis BCL Inhibitor Antitumor Bcl-2 Family inhibit Bcl2-BH4 domain Anticancer BDA 366 Antiapoptotic function BDA366 Lung cancer inhibitor