Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].
説明 | BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2]. |
ターゲット&IC50 | CRTH2 (mouse):3.7 nM (in CRTH2 transfected cells), CRTH2 (human):4.5 nM (in CRTH2 transfected cells) |
In vitro | BI-671800 (compound A) exhibits low nM potency as a potent small-molecule antagonist of human or mouse CRTH2 in transfected cells[1]. |
In vivo | BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1]. BI-671800 (compound A) also effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3]. |
別名 | AP-761, Cmpd A |
分子量 | 501.5 |
分子式 | C25H26F3N5O3 |
CAS No. | 1093108-50-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 130 mg/mL (259.22 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BI-671800 1093108-50-9 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor GPR BI 671800 Inhibitor AP 761 inhibit BI671800 AP-761 AP761 Cmpd A inhibitor