Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).
説明 | BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor). |
ターゲット&IC50 | NPYY1 receptor:0.38 nM(human), NPYY1 receptor:0.72 nM (rat) |
In vivo | BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding response mediated by 1 μg NPY. BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting [1]. BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels [2]. |
分子量 | 643.66 |
分子式 | C31H36F3N7O5 |
CAS No. | 191868-14-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (155.36 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BIBO3304 TFA 191868-14-1 GPCR/G Protein Neuroscience Neuropeptide Y Receptor Inhibitor subtype BIBO3304 inhibit insulin NPY receptor serum hyperphagia BIBO-3304 BIBO-3304 TFA oral refeeding BIBO 3304 inhibitor