Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 46,000 | |||
10 mg | 在庫あり | ¥ 76,000 | |||
25 mg | 在庫あり | ¥ 128,000 | |||
50 mg | 在庫あり | ¥ 180,000 | |||
100 mg | 在庫あり | ¥ 250,500 | |||
500 mg | 在庫あり | ¥ 512,000 |
説明 | BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease. |
ターゲット&IC50 | ETA:0.150 μM, ETA:0.055 μM(Ki ) |
In vitro | BMS-182874 (dimethyla minonalogue 11) is an effective functional antagonist of ETA-induced intracellular Ca2+ increase, with an IC50 value of 0.150 μM in vs-A10 cells. Ki value is 0.055 μM. The KB value in the rabbit carotid artery ring is 0.520 μM/[1] |
In vivo | BMS 182874 (100 μM/kg; Single oral) administration causes a slow decrease of 25% in arterial blood pressure from the control level. After 12 and 24 hours of administration, arterial blood pressure remained 12% lower than the control level.[1] |
別名 | BMS182874, BMS-182874 |
分子量 | 345.42 |
分子式 | C17H19N3O3S |
CAS No. | 153042-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (159.23 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS 182874 153042-42-3 GPCR/G Protein Endothelin Receptor BMS182874 BMS-182874 Inhibitor inhibitor inhibit