store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,500 |
説明 | BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP). |
ターゲット&IC50 | β-Amyloid (HEK293 cells):7 nM, β-Amyloid (HEK293 cells):7 nM |
In vitro | BMS-299897 (1 μM) decreases these peptides to levels ranging from 20 to 50% of the vehicle control. Furthermore, it leads to a reduction in the proportion of QD-BDNF signals moving in the retrograde direction (p=0.0198) while concurrently increasing the proportion of signals moving in the anterograde direction (p=0.0147).[2] |
In vivo | BMS-299897 (0.1-1 nmol/mouse; male Swiss mice; one week) blocks the increase in Aβ1-42 content and decreases Aβ1-40 levels significantly. The compound does not affect the Aβ25-35-induced increase in hippocampal lipid peroxidation. Behaviorally, BMS-299897 blocks the Aβ25-35-induced deficits in spontaneous alternation or novel object recognition, using a 1 h intertrial time interval. The co-administration of the γ-secretase inhibitor BMS-299897, in the 0.1-1 μmol/mouse dose range, completely blocks the Aβ25-35-induced increase in Aβ1-42 content.[1] |
分子量 | 511.94 |
分子式 | C24H21ClF3NO4S |
CAS No. | 290315-45-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.0 mg/mL (52.7 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS 299897 290315-45-6 Neuroscience Proteases/Proteasome Stem Cells Beta Amyloid Gamma-secretase BMS299897 BMS-299897 Inhibitor inhibitor inhibit