Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42 fibril aggregates. CGP52411 can be used in studies about Alzheimer's diseases.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 60,500 | |||
25 mg | 在庫あり | ¥ 121,500 | |||
50 mg | 在庫あり | ¥ 176,500 | |||
100 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 41,000 |
説明 | CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42 fibril aggregates. CGP52411 can be used in studies about Alzheimer's diseases. |
ターゲット&IC50 | EGFR:0.3 μM, β-Amyloid: |
In vitro |
In A431 cells, CGP52411 (0-100 μM) dose-dependently inhibits autophosphorylation and c-src autophosphorylation with IC50s of 1 μM and 16 μM, respectively. CGP52411 reduces tyrosine phosphorylation of p185c-erbB2 in a concentration-dependent manner(IC50 = 10 μM)[1]. CGP52411 inhibits c-src kinase (IC50 = 16 μM) and PKC isozymes isolated from porcine brain (IC50 = 80 μM)[1]. |
In vivo | In female BALB/c nude mice, CGP52411 (6.3 mg/kg-50 mg/kg; orally) shows antitumor efficacy[1]. |
別名 | DAPH |
分子量 | 329.35 |
分子式 | C20H15N3O2 |
CAS No. | 145915-58-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (273.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CGP52411 145915-58-8 Angiogenesis JAK/STAT signaling Neuroscience Tyrosine Kinase/Adaptors EGFR Beta Amyloid DAPH CGP 52411 CGP-52411 Inhibitor inhibitor inhibit