Powder: -20°C for 3 years | In solvent: -80°C for 1 year
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 7,000 | |||
10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 22,500 | |||
50 mg | 在庫あり | ¥ 38,500 | |||
100 mg | 在庫あり | ¥ 57,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment. |
In vitro | The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15 ± 0.09 μM [1]. |
In vivo | It was found that oral administration of δ-secretase inhibitor 11 (10 mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1] |
分子量 | 220.23 |
分子式 | C10H12N4O2 |
CAS No. | 842964-18-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.2 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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δ-secretase inhibitor 11 842964-18-5 Apoptosis Neuroscience Proteases/Proteasome Caspase Beta Amyloid δ-Secretase inhibitor 11 CNS diseases Alzheimer's disease δ secretase inhibitor 11 β-amyloid peptide oxygen-glucose deprivation amyloid precursor protein Abeta asparagine endopeptidase Inhibitor APP AEP Amyloid-β delta-secretase inhibitor 11 Pala cells δsecretase inhibitor 11 inhibit inhibitor