Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 21,500 | |||
5 mg | 在庫あり | ¥ 51,500 | |||
10 mg | 在庫あり | ¥ 75,500 | |||
25 mg | 在庫あり | ¥ 128,000 | |||
50 mg | 在庫あり | ¥ 180,000 | |||
100 mg | 在庫あり | ¥ 250,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 73,500 |
説明 | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay). |
In vitro | The small-molecule inhibitors of the PD-1/PD-L1 interaction, BMS-1001 , ?bind to human PD-L1 and block its interaction with PD-1, when tested on isolated proteins.?The compounds present low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1.?BMS-1001 alleviate the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.?Moreover, the compounds were effective in attenuating the inhibitory effect of the cell surface-associated PD-L1. |
分子量 | 594.7 |
分子式 | C35H34N2O7 |
CAS No. | 2113650-03-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.94 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS-1001 2113650-03-4 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 BMS 1001 BMS1001 Inhibitor inhibitor inhibit