Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 43,500 | |||
10 mg | 在庫あり | ¥ 72,500 | |||
25 mg | 在庫あり | ¥ 121,500 | |||
50 mg | 在庫あり | ¥ 176,500 | |||
100 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 60,000 |
説明 | BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes. |
In vitro | BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. It presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. |
分子量 | 631.11 |
分子式 | C35H35ClN2O7 |
CAS No. | 2113650-04-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.5 mg/mL(18.22 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS-1001 hydrochloride 2113650-04-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 Inhibitor BMS 1001 BMS-1001 Hydrochloride inhibit ICB toxicity BMS1001 immune checkpoint BMS1001 Hydrochloride BMS 1001 hydrochloride BMS 1001 Hydrochloride BMS-1001 BMS1001 hydrochloride low inhibitor