Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 20,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 51,000 | |||
50 mg | 在庫あり | ¥ 85,500 | |||
100 mg | 在庫あり | ¥ 128,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
ターゲット&IC50 | CDC25B2:3.9 μM, CDC25A:2.4 μM, CDC25B3:6.3 μM, CDC25C:5.4 μM, CDC25C-cat:4.6 μM |
In vitro | The in vitro impact of BN82002 on the proliferation of various human tumor cell lines has been assessed, with menadione serving as a control due to its documented proliferation inhibitory properties. All tested cell lines exhibit sensitivity to both BN82002 and menadione, demonstrating concentration-dependent inhibition within the low micromolar range. Among these, the pancreatic cancer cell line MIA PaCa-2 is the most affected by BN82002, showing an IC50 of 7.2 μM, while the colon cancer cell line HT-29 shows the least sensitivity with an IC50 of 32.6 μM. This range of inhibitory concentration for BN82002 closely matches that observed with menadione (5-15 μM). Further findings indicate that a 50 μM concentration of BN82002 completely halts cell proliferation. Although the influence on cell cycle distribution is relatively mild, there is a noted decrease in the S phase and an increase in cells with G1 and G2 DNA content, hinting at cell cycle arrest at various stages due to BN82002 treatment. |
別名 | CDC25 Phosphatase Inhibitor I |
分子量 | 359.42 |
分子式 | C19H25N3O4 |
CAS No. | 396073-89-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (417.34 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BN82002 396073-89-5 Metabolism Phosphatase CDC25C CDC25A inhibit BN 82002 CDC25B3 MIA PaCa-2 Inhibitor CDC25B2 BN-82002 CDC25 Phosphatase Inhibitor I inhibitor