Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD0209 is a highly selective and potent GSK3 inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 85,500 | |||
25 mg | 在庫あり | ¥ 144,500 | |||
50 mg | 在庫あり | ¥ 206,000 | |||
100 mg | 在庫あり | ¥ 280,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 60,000 |
説明 | BRD0209 is a highly selective and potent GSK3 inhibitor. |
ターゲット&IC50 | GSK-3β:5 nM, GSK-3α:19 nM |
In vitro | BRD0209 showed concentration-dependent inhibition of Tau with cellular EC50s of 1.76 μM, respectively, in SH-SY5Y cells using ELISA. Treatment of SH-SY5Y cells with BRD0209 (10 μM) significantly inhibited GSK3 kinase activity within 30 min, as seen in the decrease in phospho-CRMP2 and phospho-β-catenin. BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively).BRD0209 treatment caused a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24 h) [1]. |
別名 | BRD-0209, BRD 0209 |
分子量 | 347.45 |
分子式 | C22H25N3O |
CAS No. | 1597439-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.47 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BRD0209 1597439-87-6 PI3K/Akt/mTOR signaling Stem Cells GSK-3 BRD-0209 BRD 0209 Inhibitor inhibitor inhibit