Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
説明 | BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro. |
In vitro | BT-13 stimulates phosphorylation of RET and RET-dependent intracellular signaling but activated neither BDNF receptor TrkB nor NGF receptor TrkA nor intracellular signaling in the absence of RET. |
In vivo | In rats with surgery-induced neuropathy, BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons. |
分子量 | 517.54 |
分子式 | C23H27F4N3O4S |
CAS No. | 924537-98-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (48.31 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BT-13 924537-98-4 Apoptosis Tyrosine Kinase/Adaptors c-RET RET BT 13 Inhibitor inhibit BT13 inhibitor