Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 induces apoptosis and can be used in the study of prostate cancer, BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation and cardiovascular disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 25,000 | |||
10 mg | 在庫あり | ¥ 36,500 | |||
25 mg | 在庫あり | ¥ 61,000 | |||
50 mg | 在庫あり | ¥ 91,000 |
説明 | BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 induces apoptosis and can be used in the study of prostate cancer, BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation and cardiovascular disease. |
ターゲット&IC50 | α2β1:130 nM (EC50) |
In vitro | BTT-3033 and BTT-3034 inhibited cell adhesion to rat tail collagen I with EC50 values of 130 and 160 nM, respectively, and corresponding Emax values of 97 and 86% .Neither BTT-3033 nor BTT-3034 (at EC50 concentrations) inhibited the adhesion of MG-63 cells to vitronectin, 120-kDa fibronectin or 40-kDa fibronectin, assays that measured αV, α5β1, and α4β1 integrin function, respectively [2]. |
In vivo | Integrin α2β1 function blocking sulfonamides BTT-3016, BTT-3033(oral administration, 10 mg/kg) and BTT-3034 have anti-inflammatory effects in PAF-stimulated air pouch model[1]. |
別名 | BTT3033, BTT 3033 |
分子量 | 465.5 |
分子式 | C23H20FN5O3S |
CAS No. | 1259028-99-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (214.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BTT-3033 1259028-99-3 Apoptosis Cytoskeletal Signaling Integrin BTT3033 BTT 3033 Inhibitor inhibitor inhibit