Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 49,000 | |||
10 mg | 在庫あり | ¥ 89,500 | |||
25 mg | 在庫あり | ¥ 150,500 | |||
50 mg | 在庫あり | ¥ 214,000 | |||
100 mg | 在庫あり | ¥ 291,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 56,000 |
説明 | CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element. |
In vitro | In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE [1]. CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells[2]. |
In vivo | CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) [1]. |
別名 | TP319, CDDO ethyl amide, RTA 405 |
分子量 | 518.73 |
分子式 | C33H46N2O3 |
CAS No. | 932730-51-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (57.8 mM)
You can also refer to dose conversion for different animals. 詳細
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CDDO-EA 932730-51-3 Immunology/Inflammation Nrf2 TP319 TP 319 CDDO ethyl Amide RTA405 CDDO ethyl amide TP-319 RTA 405 RTA-405 Inhibitor inhibitor inhibit