Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface and is a potential compound for the study of cystic fibrosis.
説明 | CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface and is a potential compound for the study of cystic fibrosis. |
ターゲット&IC50 | CFTR:(EC50)130 nM , CFTR:130 nM(EC50) |
In vitro | CFTR corrector 4 (Compound 13) possesses high potency and efficacy with an EC50 of 0.028 μM in HBE-TECC assay that assesses the CFTR function. CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with an EC50 value of 130 nM in the cell surface expression (CSE-HRP) assay.[1] |
分子量 | 539.52 |
分子式 | C29H27F2NO7 |
CAS No. | 1918142-34-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (92.67 mM)
You can also refer to dose conversion for different animals. 詳細
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CFTR corrector 4 1918142-34-3 Membrane transporter/Ion channel CFTR Inhibitor inhibitor inhibit