keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約8-10 週間 | ¥ 11,000 |
2 mg | 約8-10 週間 | ¥ 16,000 |
5 mg | 約8-10 週間 | ¥ 26,000 |
10 mg | 約8-10 週間 | ¥ 43,500 |
25 mg | 約8-10 週間 | ¥ 86,500 |
50 mg | 約8-10 週間 | ¥ 133,000 |
100 mg | 約8-10 週間 | ¥ 190,000 |
1 mL * 10 mM (in DMSO) | 約8-10 週間 | ¥ 29,000 |
説明 | CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). |
In vitro | CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells[1]. |
In vivo | CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin[1]. |
分子量 | 550.69 |
分子式 | C31H42N4O5 |
CAS No. | 334998-36-6 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.9 mg/mL (165.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CUR61414 334998-36-6 GPCR/G Protein Stem Cells Hedgehog/Smoothened CUR 61414 CUR-61414 Inhibitor inhibitor inhibit