Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
2 mg | 在庫あり | ¥ 13,500 | |||
5 mg | 在庫あり | ¥ 21,500 | |||
10 mg | 在庫あり | ¥ 33,500 | |||
25 mg | 在庫あり | ¥ 58,000 | |||
50 mg | 在庫あり | ¥ 92,000 | |||
100 mg | 在庫あり | ¥ 137,000 | |||
500 mg | 在庫あり | ¥ 296,000 |
説明 | Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. |
In vitro | LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. [1] |
In vivo | LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. [2] |
別名 | LY2940680 |
分子量 | 512.5 |
分子式 | C26H24F4N6O |
CAS No. | 1258861-20-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.64 mg/mL (11 mM)
You can also refer to dose conversion for different animals. 詳細
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Taladegib 1258861-20-9 GPCR/G Protein Stem Cells Hedgehog/Smoothened Smo inhibit LY 2940680 LY-2940680 LY2940680 Inhibitor Smoothened inhibitor