Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 55,000 | |||
10 mg | 在庫あり | ¥ 82,500 | |||
25 mg | 在庫あり | ¥ 136,000 | |||
50 mg | 在庫あり | ¥ 194,500 | |||
100 mg | 在庫あり | ¥ 259,500 |
説明 | Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. |
In vitro | Cilobradine hydrochloride is an HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine hydrochloride inhibits WT mHCN2 channel current by 86%. In contrast, I432A and A425G channel currents were only reduced by 14% and 19%, respectively, by this concentration of Cilobradine hydrochloride. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine hydrochloride (8 ± 2% inhibition)[1]. |
別名 | DK-AH 269 |
分子量 | 519.07 |
分子式 | C28H39ClN2O5 |
CAS No. | 186097-54-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5mg/mL (216.7mM)
H2O: 91 mg/mL (175.31mM)
You can also refer to dose conversion for different animals. 詳細
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Cilobradine hydrochloride 186097-54-1 Membrane transporter/Ion channel HCN Channel Cilobradine Hydrochloride DK-AH269 DK-AH-269 DK-AH 269 Inhibitor inhibitor inhibit