Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.
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2 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,500 | |||
25 mg | 在庫あり | ¥ 39,000 | |||
50 mg | 在庫あり | ¥ 72,500 | |||
100 mg | 在庫あり | ¥ 108,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,000 |
説明 | Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells. |
In vitro | Treatment with 0-20 μM Clofilium inhibits viability and proliferation in a time- and concentration-dependent manner in HL-60 cells. Cell viability is significantly reduced in HL-60 cells treated with 2.5 μM to 10 μM Clofilium After 12 hours. Treatment with 10 μM Clofilium induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP.. However, the expression of Bcl-2 and Bax proteins does not change significantly[1]. |
分子量 | 510.17 |
分子式 | C28H44ClNO3S |
CAS No. | 92953-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (196.01 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Clofilium tosylate 92953-10-1 Membrane transporter/Ion channel Potassium Channel Clofilium inhibit Apoptosis Inhibitor KcsA Clofilium Tosylate inhibitor