Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 8,000 | |||
100 mg | 在庫あり | ¥ 11,500 | |||
200 mg | 在庫あり | ¥ 18,500 | |||
500 mg | 在庫あり | ¥ 34,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals. |
In vitro | Closantel inhibits drug resistant S. aureus and E. faecium with MICs of 1 μg/mL and 1 μg/mL. Closantel inhibits MRSA and E.faecalis with MICs of 2 μg/mL and 1 μg/mL. [1] Closantel completely blocks the infection of host cells with E. chaffeensis or A. phagocytophilum, treatment of infected cells 1 day post infection with closantel clears infection in dose-dependent manner. Closantel inhibits the autokinase activities of the three E. chaffeensis sensor kinases from E. chaffeensis. [2] Closantel (50 μg/mL) causes an initial burst of contractions of much greater amplitude and frequency than normal in tissue vessel, the stimulation of amplitude and frequency lasted for nearly 15 min and is accompanied by a rise in muscle tone, which reaches a maximum at 16 min, at a level greater than 1.5 times the maximal normal amplitude. [3] |
In vivo | Closantel (10 mg/kg) results in gross surface damage from 24 hours onwards in rats administrated with 25 metacercarial cysts of F. hepatica, in the form of erosion of the anterior and posterior extremities of the fluke and large-scale sloughing of the tegument on both dorsal and ventral surfaces. [3] Closantel (7.5 mg/kg) combined with broad-spectrum anthelmintic is very effective against H. contortus but ineffective against Trichostrongylus spp in lambs. [4] Closantel significantly reduces isotope levels in closantel-resistant adult Haemonchus contortus infected sheep. [5] |
分子量 | 685.06 |
分子式 | C22H13Cl2I2N2O2·Na |
CAS No. | 61438-64-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (135.8 mM)
Ethanol: 93 mg/mL (135.8 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Closantel Sodium 61438-64-0 Microbiology/Virology Antibacterial Parasite Closantel Onchocerca Inhibitor volvulus fromprotozoans chitotriosidase salicylanilide inhibit O. volvulus halogenated chitinase OvCHT1 inhibitor