Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 18,000 | |||
10 mg | 在庫あり | ¥ 28,500 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 98,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 19,500 |
説明 | Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases. |
In vitro | Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation [1]. Coumestrol inhibits viability and invasion and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of the proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2, and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner [2]. |
植物由来 |
分子量 | 268.22 |
分子式 | C15H8O5 |
CAS No. | 479-13-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25mg/mL (93.21 mM)
Methanol: 20 mg/mL (74.57 mM)
You can also refer to dose conversion for different animals. 詳細
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Coumestrol 479-13-0 Endocrinology/Hormones Estrogen Receptor/ERR Inhibitor inhibit inhibitor