Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value for antagonism of histamine-induced positive chronotropic responses in the right atrium of isolate guinea pigs was 0.041.Dalcotidine improves the quality of ulcer healing, and may contribute to a reduction in ulcer recurrence and relapse rates.
説明 | Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value for antagonism of histamine-induced positive chronotropic responses in the right atrium of isolate guinea pigs was 0.041.Dalcotidine improves the quality of ulcer healing, and may contribute to a reduction in ulcer recurrence and relapse rates. |
ターゲット&IC50 | H2 receptor:0.04 mumol/l |
別名 | KU 1257, KU-1257 |
分子量 | 319.44 |
分子式 | C18H29N3O2 |
CAS No. | 120958-90-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.6 mg/mL (11.27 mM)
You can also refer to dose conversion for different animals. 詳細
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Dalcotidine 120958-90-9 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor KU 1257 KU-1257 KU1257 Inhibitor inhibitor inhibit