Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 46,000 | |||
10 mg | 在庫あり | ¥ 73,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 48,500 |
説明 | Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK. |
In vitro | Treatment of C2C12 myoblasts with 500 nM dehydrocorydrine increased the expression level of muscle-specific proteins (including MyoD, myogenin and myosin heavy chain). Treatment with dehydrocorydrine can increase p38 MAPK activation and the interaction between MyoD and E protein. In addition, the treatment of dehydrohydroxyproline can restore the defects of differentiation-induced p38 MAPK activation and differentiation of myoblasts in C2C12 myoblasts induced by the differentiated early growth receptor protein Cdo. Dehydrohydroxyproline significantly inhibits the proliferation of MCF-7 cells in a dose-dependent manner, which can be reversed by the caspase-8 inhibitor Z-IETD-FMK. Dehydrohydroxyproline increases DNA fragments without affecting ΔΨm. Western blot analysis showed that dehydrocorydrine increased dose-dependently Bax protein expression and decreased Bcl-2 protein expression. In addition, dehydrohydroxyproline induces caspase-7,-8 activation and PARP cleavage without affecting caspase-9. These results indicate that dehydrohydroxyproline inhibits the proliferation of MCF-7 cells by inducing apoptosis by regulating Bax/Bcl-2, activating caspase and cleaving PARP. |
In vivo | Dehydrocobaltate (3.6, 6 or 10 mg/kg, intraperitoneal injection) showed a dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test and significantly reduced formalin-induced mice Pain reaction. In the formalin test, dehydrocorydrine can reduce the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. It was confirmed that dehydroyanhusine has an analgesic effect on mice. |
別名 | 13-Methylpalmatine chloride |
分子量 | 401.88 |
分子式 | C22H24ClNO4 |
CAS No. | 10605-03-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24 mg/mL(59.72 mM)
You can also refer to dose conversion for different animals. 詳細
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Dehydrocorydaline chloride 10605-03-5 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair MAPK Microbiology/Virology Proteases/Proteasome Caspase Parasite BCL PARP p38 MAPK inhibit Bcl-2 Family Dehydrocorydaline Chloride poly ADP ribose polymerase 13-Methylpalmatine Dehydrocorydaline 13-Methylpalmatine Chloride Inhibitor 13-Methylpalmatine chloride inhibitor