Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
説明 | ML311 is a selective inhibitor of the Mcl-1/Bim interaction. |
In vitro | ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1]. |
分子量 | 415.45 |
分子式 | C23H24F3N3O |
CAS No. | 315698-17-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL
H2O: Insoluble
Ethanol: 20 mg/mL
You can also refer to dose conversion for different animals. 詳細
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ML311 315698-17-0 Apoptosis BCL Inhibitor ML 311 Bcl-2 Family ML-311 inhibit inhibitor