Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Deriglidole (SL 86-0715) is a peripheral adrenergic receptor antagonist that is a selective inhibitor of alpha2 receptors. Deriglidole inhibits colistin and Idazoxan but does not show activity against prazosin and rat cortical and human platelet α2-adrenergic receptors.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 105,500 |
5 mg | 在庫あり | ¥ 243,500 |
10 mg | 在庫あり | ¥ 326,000 |
25 mg | 在庫あり | ¥ 482,000 |
50 mg | 在庫あり | ¥ 592,500 |
100 mg | 在庫あり | ¥ 780,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 182,000 |
説明 | Deriglidole (SL 86-0715) is a peripheral adrenergic receptor antagonist that is a selective inhibitor of alpha2 receptors. Deriglidole inhibits colistin and Idazoxan but does not show activity against prazosin and rat cortical and human platelet α2-adrenergic receptors. |
In vitro | Deriglidole is a specific inhibitor of α2-receptors. Deriglidole inhibits the binding of [3H] clonidine and [3H] imidazole x, while showing no inhibitory effect on the binding of [3H] prazosin to rat cortex and human platelet α2-adrenergic receptors. Furthermore, it demonstrates greater effectiveness than idazolide in selectively targeting peripheral receptors.[1] |
In vivo | In mouse pancreatic beta-cells that both deriglidole and SL86.0714 inhibit ATP-sensitive K+ channel with similar potency whereas alpha2-adrenoceptors are blocked only by deriglidole. In diabetic rats, SL84.0418 and deriglidole (10 mg/kg i.p.) fully normalized glucose tolerance whereas SL86.0714 and tolbutamide only slightly improved it. Five min after deriglidole administration in mice a marked and short lasting rise in insulin levels was observed, followed by a progressive reduction of glycemia.[2] |
別名 | SL 86-0715 |
分子量 | 255.36 |
分子式 | C16H21N3 |
CAS No. | 122830-14-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.5 mg/mL (127.27 mM)
You can also refer to dose conversion for different animals. 詳細
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Deriglidole 122830-14-2 GPCR/G Protein Neuroscience Adrenergic Receptor SL 86-0715 Inhibitor inhibitor inhibit