Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.
説明 | Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity. |
ターゲット&IC50 | α2-adrenoceptor (rat):25 nM, 5-HT3 receptor:0.22 μM(Ki,rat intestinal membrane), 5-HT3 receptor:0.35 μM(Ki,rat cortical membrane) |
In vivo | Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate[4]. |
別名 | Domnin, B-HT 920 dihydrochloride |
分子量 | 282.23 |
分子式 | C10H17Cl2N3S |
CAS No. | 36085-73-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (79.72 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Talipexole dihydrochloride 36085-73-1 GPCR/G Protein Neuroscience 5-HT Receptor Dopamine Receptor Adrenergic Receptor 5-hydroxytryptamine Receptor Talipexole Talipexole Dihydrochloride inhibit Domnin B-HT920 Dihydrochloride B-HT920 B-HT 920 Inhibitor B-HT-920 B-HT 920 Dihydrochloride B-HT 920 dihydrochloride Serotonin Receptor Beta Receptor B-HT-920 Dihydrochloride inhibitor