Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cynomolgus monkey, mouse, and rat, respectively. It exhibits strong affinity for human MC1R and MC4R, with Ki values of 2.26 nM and 32.9 nM, respectively. This compound is applied in the study of skin pigmentation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 43,500 | |||
10 mg | 在庫あり | ¥ 64,000 | |||
25 mg | 在庫あり | ¥ 109,000 | |||
50 mg | 在庫あり | ¥ 156,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 58,500 |
説明 | Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cynomolgus monkey, mouse, and rat, respectively. It exhibits strong affinity for human MC1R and MC4R, with Ki values of 2.26 nM and 32.9 nM, respectively. This compound is applied in the study of skin pigmentation. |
ターゲット&IC50 | MC1R (mouse):1.14 nM (EC50), MC5R (human):486 nM (Ki), MC1R (cynomolgus monkey):3.91 nM (EC50), MC3R (human):1420 nM (Ki), MC4R (human):32.9 nM (Ki), MC4R (human):79.6 nM (EC50), MC1R (rat):0.251 nM (EC50), MC1R (human):2.26 nM (Ki), MC1R (human):8.16 nM (EC50), MC2R (human):>10000 nM (EC50) |
In vitro | Dersimelagon (0, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100, 300 pM; 3 days) enhances eumelanin synthesis in B16F1 cells in a concentration-dependent fashion, demonstrating an EC50 of 13 pM[1]. |
In vivo | Dersimelagon (0.003, 0.03, 0.3, 3 mg/kg; p.o. for 6 days) induces coat colour darkening in Ay/a mice in 0.3 and 3 mg/kg[1]. |
別名 | MT-7117 |
分子量 | 675.75 |
分子式 | C36H45F4N3O5 |
CAS No. | 1835256-48-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.76 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Dersimelagon 1835256-48-8 GPCR/G Protein Neuroscience Melanocortin Receptor MT7117 MT-7117 MT 7117 Inhibitor inhibitor inhibit