Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats.
説明 | Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats. |
In vitro | Droloxifene induces apoptosis in MCF-7 cells(10 nM; 16-18 hours)[1]. |
In vivo | Droloxifene (5-20 mg/kg,P.o.;Daily for 4 weeks can bring THE BMD of DFM up to 10mg/kg and completely prevent OVX from reducing the BMC and BMD of DFM at 20mg /kg/day[1]. |
別名 | 3-Hydroxytamoxifen |
分子量 | 387.51 |
分子式 | C26H29NO2 |
CAS No. | 82413-20-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (116.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Droloxifene 82413-20-5 Endocrinology/Hormones Estrogen Receptor/ERR 3-Hydroxytamoxifen Inhibitor inhibitor inhibit