Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 14,500 | |||
5 mg | 在庫あり | ¥ 30,500 | |||
10 mg | 在庫あり | ¥ 51,500 | |||
25 mg | 在庫あり | ¥ 91,500 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 41,000 |
説明 | EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. |
ターゲット&IC50 | ARTD1/PARP1:45 nM |
In vitro | The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%[1]. |
In vivo | EB-47, at a concentration of 2 μM for a duration of 5 days, reduces the number of embryo implantation sites and the quantity of blastocysts observed on day 5. PARP1 is involved in the embryo implantation process[1]. |
分子量 | 537.53 |
分子式 | C24H27N9O6 |
CAS No. | 366454-36-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (111.62 mM)
You can also refer to dose conversion for different animals. 詳細
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EB-47 366454-36-6 Chromatin/Epigenetic DNA Damage/DNA Repair PARP EB47 EB 47 Inhibitor inhibitor inhibit