Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.
説明 | EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1. |
ターゲット&IC50 | EGFR (L858R/T790M/C797S):18 nM |
In vitro | EGFR-IN-11 (0.1 nM-10 µM) shows anti-proliferation with IC50s of 0.88 nM, 0.20 µM and 2.91 μM for HCC827, H1975 and A549 cells. EGFR-IN-11 (10nM-10 µM) suppresses the phosphorylation of EGFR in a concentration-dependent manner in the HCC827, H1975 and A549 cells[1]. |
分子量 | 573.71 |
分子式 | C29H35N9O2S |
CAS No. | 2463200-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (196.1 mM ), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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EGFR-IN-11 2463200-44-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR EGFRIN11 EGFR IN 11 Inhibitor inhibitor inhibit