Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 67,000 | |||
10 mg | 在庫あり | ¥ 111,000 | |||
25 mg | 在庫あり | ¥ 181,000 | |||
50 mg | 在庫あり | ¥ 248,000 | |||
100 mg | 在庫あり | ¥ 340,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 73,500 |
説明 | ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1]. |
ターゲット&IC50 | ELOVL6:0.35 μM, ELOVL6:994 nM(ki) |
In vitro | ELOVL6-IN-1 has sufficiently lipophilic. It has the potential to penetrate the intracellular space in a passive diffusion manner potentially[1]. |
In vivo |
ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1]. ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1]. ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1]. |
分子量 | 495.49 |
分子式 | C27H24F3N3O3 |
CAS No. | 1185736-98-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (90.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ELOVL6-IN-1 1185736-98-4 Others ELOVL6IN1 noncompetitive orally palmitoyl-CoA potent malonyl-CoA ELOVL-6-IN-1 Inhibitor selective ELOVL6 IN 1 inhibit inhibitor