Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
説明 | ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. |
ターゲット&IC50 | ERK5:0.82 μM, ERK5 MEF2D:3 μM |
In vivo | ERK5-IN-2 (compound 46) (p.o.; 100?mg/kg; CD1 mice for 7 days and CD1 nude (nu/nu) mice for 10 days) has an anti-angiogenic effect and low concentrations of haemoglobin.ERK5-IN-2 (i.v. or p.o.; 10?mg/kg for 0.083-24?hours) exhibits low intrinsic clearance and has high flux and a low efflux ratio (ER) in a caco-2?cell permeability assay in both human and mouse. |
分子量 | 388.19 |
分子式 | C17H11BrFN3O2 |
CAS No. | 1888305-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (25.76 mM)
You can also refer to dose conversion for different animals. 詳細
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ERK5-IN-2 1888305-96-1 MAPK ERK Inhibitor ERK5 IN 2 Extracellular signal regulated kinases inhibit ERK-5-IN-2 ERK5IN2 inhibitor