Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader .
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 34,000 | |||
5 mg | 在庫あり | ¥ 80,000 | |||
10 mg | 在庫あり | ¥ 114,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
100 mg | 在庫あり | ¥ 349,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 89,000 |
説明 | Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader . |
ターゲット&IC50 | ERβ:870 nM , ERα:48 nM |
In vitro | Elacestrant treatment exhibits dose-dependent inhibition of ERα expression, with an EC50 of 0.6 nM.Treatment of ER-positive MCF-7 cells with E2 results in a potent and dose-dependent increase in proliferation, with an EC50 of 4 pM.Treatment of cells with Elacestrant in the presence of 10 pM E2 resultsin a dose-dependent decrease in proliferation, with an IC50 value of 4.2 nM.Elacestrant selectively binds to and degrades the ER and is a potent antagonist of ER-positive breast cancer cell proliferation. |
In vivo | Elacestrant produces a robust and profound inhibition of tumor growth in MCF-7 xenograft models.Elacestrant preserves ovariectomy-induced bone loss and preventes the uterotropic effects of E2.Elacestrant-treated animals survived longer than those treated with either control or fulvestrant. |
別名 | RAD1901 |
分子量 | 458.63 |
分子式 | C30H38N2O2 |
CAS No. | 722533-56-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (130.82 mM)
You can also refer to dose conversion for different animals. 詳細
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Elacestrant 722533-56-4 Endocrinology/Hormones Estrogen Receptor/ERR Estrogen/progestogen Receptor inhibit Inhibitor RAD1901 RAD 1901 RAD-1901 inhibitor