Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 11,500 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 79,500 | |||
50 mg | 在庫あり | ¥ 118,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 30,500 |
説明 | Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. |
ターゲット&IC50 | RNA polymerase activity (dGTP-dependent):0.01μM(ki), DNA polymerase activity (dTTP-dependent):0.20μM(ki) |
In vitro | Emivirine is a novel nonnucleoside reverse transcriptase inhibitor that displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity in vivo. IC50 against laboratory-adapted strains of HIV-1 ranged from 1.6 to 19 nM. Against clinical isolates, the IC50 for EMV ranged from 2 to 40 nM. The Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively[1]. |
In vivo | Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity in vivo. Pharmacokinetics were linear for both rats and monkeys, and oral absorption was 68% in rats. Rats were given an oral dose of Emivirine at 10 mg/kg of body weight showed widespread distribution in tissue after 30 min. In rats given an oral dose of 250 mg/kg, there were equal levels of Emivirine in the plasma and the brain[2]. |
別名 | MKC442, MKC-442, MKC 442, DRG-0302, DRG 0302, DRG0302 |
分子量 | 302.37 |
分子式 | C17H22N2O3 |
CAS No. | 149950-60-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.8 mg/mL (15.87 mM)
You can also refer to dose conversion for different animals. 詳細
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Emivirine 149950-60-7 Microbiology/Virology Proteases/Proteasome HIV Protease MKC442 MKC-442 MKC 442 DRG-0302 DRG 0302 DRG0302 Inhibitor inhibitor inhibit