Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
説明 | Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor. |
In vivo | HM30181 to inhibit Pgp at the murine BBB.?HM30181 was shown to be approximately equipotent with the reference Pgp inhibitor tariquidar in inhibiting rhodamine 123 efflux from CCRF-CEM T cells (IC(50), tariquidar: 8.2 2.0 nM, HM30181: 13.1 2.3 nM).?PET scans with the Pgp substrate (R)-[(11)C]verapamil in FVB wild-type mice pretreated i.v. with HM30181 (10 or 21 mg/kg) failed to show significant increases in (R)-[(11)C]verapamil brain uptake compared with vehicle treated animals.?PET scans with [(11)C]HM30181 showed low and not significantly different brain uptake of [(11)C]HM30181 in wild-type, Mdr1a/b((-/-)) and Bcrp1((-/-)) mice and significantly, i.e. 4.7-fold (P<0.01), higher brain uptake, relative to wild-type animals, in Mdr1a/b((-/-))Bcrp1((-/-)) mice[1]. |
別名 | HM30181, HM30181A |
分子量 | 688.73 |
分子式 | C38H36N6O7 |
CAS No. | 849675-66-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.9 mg/mL (10.02 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Encequidar 849675-66-7 Membrane transporter/Ion channel Neuroscience P-gp MDR1 Cluster of differentiation 243 inhibit P-glycoprotein HM30181 Multidrug resistance protein 1 Inhibitor CD243 HM-30181 Pgp ABCB1 HM 30181 HM30181A inhibitor