Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 57,500 | |||
50 mg | 在庫あり | ¥ 85,000 | |||
100 mg | 在庫あり | ¥ 126,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 25,500 |
説明 | Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. |
ターゲット&IC50 | COX-2:0.026 mg/mL |
In vitro | Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant [2]. |
In vivo | Agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.3 It also suppresses production of the pro-inflammatory mediators' prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.4 |
植物由来 |
別名 | chasteberry oil |
分子量 | 466.44 |
分子式 | C22H26O11 |
CAS No. | 11027-63-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (107.19 mM)
You can also refer to dose conversion for different animals. 詳細
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Agnuside 11027-63-7 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Neuroscience COX P-gp Prostaglandin Receptor Agnoside Inhibitor inhibit chasteberry oil inhibitor