Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)
説明 | FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1) |
In vitro | FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines. |
別名 | FEN1 Inhibitor C2 |
分子量 | 232.24 |
分子式 | C12H12N2O3 |
CAS No. | 1995893-58-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (430.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FEN1-IN-4 1995893-58-7 Others flap colorectal Inhibitor endonuclease FEN1IN4 cells colon cancer inhibit FEN-1-IN-4 glioblastoma FEN1 IN 4 human FEN1 Inhibitor C2 hFEN1 inhibitor