|
T7008 |
Vacquinol-1
|
Vacquinol 1 |
JNK
|
|
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. |
|
T14214 |
AMG 511
|
|
PI3K
|
|
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG... |
|
T10140 |
4-Diethylaminobenzaldehyde
|
|
Dehydrogenase
|
|
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μM). |
|
T9575 |
MRTX9768
|
|
Histone Methyltransferase
|
|
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
|
T8961 |
GW280264X
|
Carbamic acid |
MMP
|
|
GW280264X (Carbamic acid) is an inhibitor of ADAM17 . |
|
T8657 |
KYP-2047
|
|
Others
|
|
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor. |
|
T22318 |
Taletrectinib
|
DS-6051b,AB-106 |
Trk receptor
,
ROS
,
ROS Kinase
|
|
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively. |
|
T8545 |
FEN1-IN-4
|
FEN1 Inhibitor C2 |
Others
|
|
FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1) |
|
T6303 |
CCT128930
|
|
Akt
,
PKA
,
S6 Kinase
,
Autophagy
|
|
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. |
|
T0440 |
Oxcarbazepine
|
GP 47680 |
Apoptosis
,
Sodium Channel
|
|
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T8421 |
TED-347
|
|
YAP
|
|
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability. |
|
T5622 |
BAY-218
|
AHR antagonist 1 |
AhR
,
Aryl Hydrocarbon Receptor
|
|
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line. |
|
T0192 |
Levetiracetam
|
UCB L059,SIB-S1 |
DNA Methyltransferase
,
Others
,
Calcium Channel
|
|
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... |
|
T8333 |
Aurintricarboxylic acid
|
ATA,NSC-4056,NSC4056,NSC 4056 |
Apoptosis
,
P2X Receptor
,
Influenza Virus
,
Topoisomerase
|
|
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. |
|
T6303L |
CCT128930 hydrochloride
|
CCT128930 hydrochloride(885499-61-6 Free base) |
Apoptosis
,
Akt
,
PKA
,
mTOR
,
Autophagy
|
|
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28... |
|
T41151L |
K34c hydrochloride
|
K34c hydrochloride(939769-93-4 Free base) |
Integrin
|
|
K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study. |
|
T5017 |
Nimustine Hydrochloride
|
Nidran hydrochloride |
Apoptosis
,
Others
,
DNA Alkylator/Crosslinker
,
DNA/RNA Synthesis
|
|
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma. |
|
T15373 |
Gboxin
|
|
ATPase
,
Mitochondrial Metabolism
|
|
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity. |
|
T16754 |
RIPGBM
|
|
Apoptosis
|
|
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM). |
|
T40222 |
FTO-IN-3
|
|
Others
|
|
FTO-IN-3 is a FTO inhibitor. FTO-IN-3 impairs self-renewal in glioblastoma stem cells. |
|
T5335 |
S-Gboxin
|
|
Others
|
|
S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM, IC50: 470 nM). |
|
T10655 |
C-Met inhibitor 1
|
|
c-Met/HGFR
|
|
c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer. |
|
T60077 |
SCP1-IN-1
|
|
Others
|
|
SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. In some glioblastoma cells, the high level of REST protein... |
|
T19807 |
Dithiazanine iodide
|
Delvex,Telmide,Vercidon,Abminthic,Netocyd,NSC 221154 |
Others
|
|
Dithiazanine iodide (Netocyd) is a benzothiazole. It has been used as an antinematodal agent. It also has been effective as a nanoparticle in treating glioblastoma. |
|
T33467 |
MOMIPP
|
|
PI3K
|
|
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2]. |
|
T9411 |
KX2-361
|
|
Others
,
Microtubule Associated
,
Src
|
|
KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma |
|
T77706 |
4-Borono-L-phenylalanine
|
(s)-2-amino-3-(4-boronophenyl)propanoic acid,L-p-Boronophenylalanine |
Others
|
|
4-Borono-L-phenylalanine has antitumor activity and may be used in clinical trials of boron neutron capture therapy for the treatment of melanoma and glioblastoma multiforme. |
|
T60102L |
Dimethylaminomicheliolide HCl
|
|
PKM
|
|
Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations. |
|
T21463 |
Temozolomide Acid
|
TMZA |
Others
|
|
Temozolomide Acid (TMZA) is a metabolite of temozolomide (TMZ). Temozolomide processes anticancer activity in vitro. Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocyt... |
|
T11728 |
JR-AB2-011
|
|
mTOR
|
|
JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 μM) and is cytotoxic in glioblastoma [1]. |
|
T2116 |
AEE788
|
NVP-AEE 788 |
Apoptosis
,
EGFR
,
c-Fms
,
FLT
,
Bcr-Abl
|
|
AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors. |
|
T9089 |
FTO-IN-1
|
UUN44923 |
Others
|
|
UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a h... |
|
T60039 |
KSQ-4279
|
USP1-IN-1 |
PARP
,
DUB
|
|
KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... |
|
T23016 |
MRS1220
|
MRS 1220 |
Adenosine Receptor
|
|
MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic promise for central nervous system disease research. It effectivel... |
|
T2365 |
Pilaralisib
|
SAR245408,XL-147 |
PI3K
|
|
Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid... |
|
T61046 |
Anticancer agent 43
|
|
Apoptosis
|
|
Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in ... |
|
T11067 |
VX-984
|
M9831 |
DNA-PK
|
|
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commo... |
|
T29028 |
TZD18
|
TZD-18,TZD 18 |
|
|
TZD18, a novel PPAR alpha/gamma dual agonist, inhibits cell growth and induces apoptosis in human glioblastoma T98G cells. |
|
T11268 |
FD 12-9
|
Ac12Az9 |
Others
|
|
FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. |
|
T29233 |
Z-LLNle-CHO
|
|
|
|
Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response. |
|
T40221 |
FTO-IN-2
|
|
|
|
FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells. |
|
T10737 |
CDK4/6-IN-3
|
|
CDK
|
|
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM. |
|
T40872 |
17-AEP-GA
|
|
|
|
17-AEP-GA is a highly effective HSP90 antagonist compound that exhibits potent inhibition against the proliferation, survival, migration, and invasion of glioblastoma cells. Additionally, it demonstrates ADCs Toxin activ... |
|
T70890 |
ML309
|
|
|
|
ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers c... |
|
T27052 |
CMP3a
|
CMP-3a,CMP 3a |
|
|
CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destab... |
|
TP1589L |
EGFRvIII peptide PEPvIII acetate
|
|
Others
|
|
EGFRvIII peptide PEPvIII acetate is a tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms and enhances tumorigenicity. |
|
T81278 |
Rhizochalinin
|
Rhiz |
|
|
Rhizochalinin (Rhiz), a cytotoxic sphingolipid, impedes proliferation in glioblastoma cells by promoting apoptosis, arresting the cell cycle at the G2/M phase, and inhibiting autophagy, making it a valuable agent for hum... |
|
T76550 |
CooP
|
|
|
|
CooP, a linear glioblastoma-targeting nonapeptide, interacts with the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) found in glioblastoma cells and their associated blood vessels. This interaction... |
|
T11118 |
Duocarmycin SA
|
|
Others
|
|
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom... |
|
T61608 |
ANO1-IN-2
|
|
|
|
ANO1-IN-2 (Compound 10q) is a potent and selective ANO1 channel blocker. It exhibits an IC50 value of 1.75 μM against ANO1 and 7.43 μM against ANO2. Furthermore, ANO1-IN-2 demonstrates significant anti-proliferative acti... |
