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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9151 | Teplinovivint | Wnt/beta-catenin | |
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research. | |||
T9148 | KA2507 | HDAC | |
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM. | |||
T9202 | DDO-5936 | HSP | |
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor. | |||
T9810 | TNIK-IN-5 | Wnt/beta-catenin | |
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity. | |||
T9693 | TBAP-001 | Raf | |
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay. | |||
T9963 | MPT0B390 | HDAC | |
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis. | |||
T60037 | SR15006 | DNA/RNA Synthesis | |
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM). | |||
T4985 | Neticonazole Hydrochloride | Antifungal | |
Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes. | |||
T1867 | Otenaproxesul | ATB 346 | Apoptosis , COX |
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. | |||
T24437 | MCP110 | MCP-110,MCP 110 | Raf , Ras |
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors. | |||
T11285 | FIDAS-5 | Others | |
FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities. | |||
T4435 | E7820 | ER68203-00 | Integrin |
E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells). | |||
T2301 | SB 202190 | FHPI,SB202190 | Apoptosis , p38 MAPK , Autophagy |
SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i... | |||
T8545 | FEN1-IN-4 | FEN1 Inhibitor C2 | Others |
FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1) | |||
T22318 | Taletrectinib | DS-6051b,AB-106 | Trk receptor , ROS , ROS Kinase |
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively. | |||
T6255 | Bromosporine | Epigenetic Reader Domain , CDK | |
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively. | |||
T9696 | β-catenin-IN-2 | Wnt/beta-catenin | |
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research. | |||
T21294 | Polmacoxib | CG-100649,CG100649,CG 100649 | COX , Carbonic Anhydrase |
Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through... | |||
T1290 | Oxiconazole nitrate | Ro 13-8996 | Others , Antibiotic , Antifection , Antifungal |
Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole... | |||
T6275 | Obatoclax Mesylate | Obatoclax,GX15-070 | BCL , Parasite , Autophagy |
Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3. | |||
T15396 | GN44028 | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine | HIF |
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H... | |||
T0459 | Sulindac | Arthrocine,MK-231,Clinoril,Sulindac sulfoxide | COX , Autophagy |
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... | |||
T2170 | SKF-96365 hydrochloride | SKF96365 | Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy |
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha... | |||
T83641 | HNPMI | Apoptosis , EGFR | |
HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, may promote apoptosis, and may be used in the study of colorectal cancer. | |||
T24642 | YH-306 | YH306,TRV055 acetate (25849-90-5 Free base) | MMP , MMP , FAK , Rho , PI3K , Src |
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis. | |||
T6894 | ML264 | CID-51003603 | DNA/RNA Synthesis , KLF |
ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer. | |||
T27454 | GSK2008607 | Raf | |
GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers. | |||
T27138 | Declopramide | OXI-104,IMO-B,3-Chloroprocainamide | Apoptosis |
Declopramide (OXI-104) is a novel chemosensitizer with antitumor activity that induces apoptosis and can be used to study colorectal cancer and inflammatory bowel disease. | |||
T68051 | Delequamine | RS 15385-197 | Adrenergic Receptor |
Delequamine (RS 15385-197) is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation. | |||
TP2320 | Pramlintide acetate(151126-32-8 free base) | Others | |
Pramlintide acetate is a polypeptide analogue of human amylin. It serves as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer. | |||
T77407 | Ensituximab | NPC-1C,NEO-102,NEO-101 | |
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer. | |||
T62061 | COX-2-IN-6 | COX , Prostaglandin Receptor | |
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u... | |||
T64066 | CSF1R-IN-3 | c-Fms , CSF-1R | |
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef... | |||
T9901A-004 | Labetuzumab | IMMU-14,hMN-14,IMMU-100 | |
Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with anticancer activity that inhibits tumor growth and is used in the study of thyroid and colorectal cancer (CRC). | |||
T22429 | SR18662 | DNA/RNA Synthesis | |
SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis. | |||
T77519 | FC-116 | FC116 | Apoptosis , Microtubule Associated |
FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation. | |||
T77660 | TINK-IN-1 | Wnt/beta-catenin | |
TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation. | |||
T19802 | B-Raf IN 11 | Raf | |
B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer. | |||
T7598 | Calcium N5-methyltetrahydrofolate | NSC173328 | Others , Antifolate |
Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers | |||
T9307 | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide | Others | |
SR18662 a.k.a. SR18662 is a KLF5 inhibitor based on the optimized structure of ML264. It inhibits the growth of colorectal cancer in vitro and in vivo. | |||
T74698 | RMC-6236 | Ras | |
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer. | |||
T2618 | LGK974 | LGK 974,LGK-974,NVP-LGK974,WNT974 | Porcupine |
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel... | |||
T28740 | SDZ-62-434 | SDZ 62 434,SDZ62434 | Platelet aggregation |
SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity that inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells for the study of leukemia, human ... | |||
T13810 | Palmitoylcarnitine chloride | Palmitoyl DL-carnitine chloride | PKC |
Palmitoylcarnitine chloride (Palmitoyl DL-carnitine chloride) is a mitochondrial fatty acid oxidation intermediate that mediates intralipid cardioprotection.Palmitoylcarnitine chloride eliminates colorectal cancer cell s... | |||
T72068 | SFI003 | Apoptosis , ROS | |
SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen spec... | |||
T21567L | Cyclosomatostatin Acetate | Cyclosomatostatin Acetate (84211-54-1 Free base) | Somatostatin |
Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell proliferation, ALDH+ cell population size, and sphere-formation in c... | |||
T1307 | Carmofur | HCFU | Nucleoside Antimetabolite/Analog , Virus Protease , SARS-CoV , DNA/RNA Synthesis |
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. | |||
T79213 | AZD4747 | Ras | |
AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma. | |||
T76792 | Sibrotuzumab | BIBH 1,Anti-Human FAP Recombinant Antibody | Others |
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP).Sibrotuzumab is used in the study of colorectal cancer and non-small cell lung cancer. | |||
T37170 | N1-Acetylspermidine hydrochloride | N1-Acetylspermidine (hydrochloride) | Endogenous Metabolite |
N1-Acetylspermidine hydrochloride is an acetyl derivative of spermidine. N1-Acetylspermidine hydrochloride is a substrate for the polyamine oxidase and selectively elevates the levels of which in human colorectal adenoca... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3055 | Liensinine Perchlorate | Apoptosis , Others | |
Liensinine is the active constituent of plumula nelambinis with anti-hypertension. | |||
TN1305 | Ethoxysanguinarine | 6-Ethoxydihydrosanguinarine | Apoptosis , AChR |
Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-... | |||
TN1465 | Cannabigerol | NOS , 5-HT Receptor , ROS | |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... | |||
T2988 | (-)-Epigallocatechin Gallate | Epigallocatechol Gallate,EGCG | Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy |
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor... | |||
T4456 | N4-Acetylcytidine | N-Acetylcytidine | Others , Endogenous Metabolite |
N4-Acetylcytidine (N-Acetylcytidine) is a modified nucleoside. N4-acetylcytidine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological mark... | |||
TQ0193 | N2,N2-Dimethylguanosine | Endogenous Metabolite | |
N2,N2-Dimethylguanosine is an urinary nucleoside. The mean levels of urinary N2,N2-Dimethylguanosine in patients with colorectal cancer are significantly higher than those in patients with intestinal villous adenoma or h... | |||
T8166 | Pennogenin 3-O-beta-chacotrioside | Autophagy | |
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Be... | |||
TJP2872 | Acevaltrate | Acevaltratum,Acetoxyvaltrate | ATPase , Others |
1. Acevaltrate (Acevaltratum) displays high cytotoxicity against GLC(4), a human small-cell lung cancer cell line, and against COLO 320, a human colorectal cancer cell line, with IC50 values of 1-6 uM. | |||
T3391 | Corosolic acid | Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid | FAK , Autophagy |
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci... | |||
T6599 | N6-methyladenosine | N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A | Others , Influenza Virus , Endogenous Metabolite |
N6-methyladenosine (NSC-29409) is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological ma... | |||
TN1237 | 3-O-Methylgallic acid | 3,4-Dihydroxy-5-methoxybenzoic acid | Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ... | |||
T36715 | Tetrac | Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid | Apoptosis , EGFR |
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac... | |||
T2938 | (E/Z)-Polydatin | Polydatin,(E/Z)-Piceid | Phospholipase |
(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be det... | |||
T8053 | N-Acetyl-L-arginine | Ac-Arg-OH | Endogenous Metabolite |
N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-... | |||
TN6617 | Malvidin-3-O-arabinoside chloride | ||
Malvidin-3-O-arabinoside chloride has antioxidant activity.It has potential preventive effect in colorectal diseases. | |||
TN3812 | Dehydrovomifoliol | AChR | |
Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three h... | |||
TN2726 | Jatrophane 5 | P-gp | |
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR). | |||
TN1324 | 6-O-Nicotinoylscutebarbatine G | Others | |
6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in th... | |||
T3425 | Polyphyllin G | Polyphyllin VII,Polyphyllin VII,Y-0166 | Others |
Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocel... | |||
TN3686 | Coccinic acid | Others | |
Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual ... | |||
T79933 | (−)-N-Hydroxyapiosporamide | NHAP | NF-κB |
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has potential applications in colorectal cancer (CRC) research [1... | |||
TMA0291 | Dehydroglyasperin D | GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK | |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit... | |||
T36815 | Chevalone C | ||
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). ... | |||
TN2727 | Jatrophane 2 | P-gp , Antifection | |
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Ja... | |||
TN1694 | Gliotoxin | Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection | |
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-04153 | RNF43 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr... | |||
TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even... | |||
TMPY-02292 | IGSF11 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins sh... | |||
TMPY-00365 | GALNT7 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either ... | |||
TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d... | |||
TMPY-04149 | RNF43 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr... | |||
TMPH-02218 | JUN Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali... | |||
TMPH-02219 | JUN Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali... | |||
TMPK-01131 | Neogenin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axo... | |||
TMPY-02572 | TXNDC17 Protein, Human, Recombinant | Human | E. coli |
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa... | |||
TMPJ-00796 | Serpin E2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal panc... | |||
TMPK-01323 | CEACAM1 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1... | |||
TMPK-00869 | CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His) | Mouse | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1... | |||
TMPK-00898 | EphB3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is co... | |||
TMPY-00497 | ZG16 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. Proteomic analyses of mucus have identified the lectin-like protein ZG16 as an abundant mucus co... | |||
TMPY-05168 | Syndecan-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde... | |||
TMPY-04249 | Syndecan-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde... | |||
TMPY-03673 | REG3B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its exp... | |||
TMPK-01306 | CDH3 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove... | |||
TMPK-00800 | CDH3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove... | |||
TMPJ-01155 | PDCD4 Protein, Human, Recombinant (His) | Human | E. coli |
Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation... | |||
TMPY-03859 | DHRS9 Protein, Human, Recombinant (His) | Human | E. coli |
Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic bioma... | |||
TMPK-00851 | CDH3 Protein, Human, Recombinant (aa 108-654, His) | Human | HEK293 Cells |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove... | |||
TMPK-01332 | LY6G6D Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz... | |||
TMPK-00753 | LY6G6D Protein, Human, Recombinant (His) | Human | HEK293 Cells |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz... | |||
TMPH-01699 | SMAD2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in t... | |||
TMPY-02046 | PFDN1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1... | |||
TMPY-03989 | PFDN1 Protein, Human, Recombinant (His) | Human | E. coli |
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1... | |||
TMPY-03329 | DPEP1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl... | |||
TMPK-00752 | LY6G6D Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz... | |||
TMPH-01048 | CEACAM5 Protein, Human, Recombinant (E398K, His) | Human | HEK293 Cells |
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion mo... | |||
TMPK-00754 | LY6G6D Protein, Human, Recombinant (His & Strep-II) | Human | HEK293 Cells |
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz... | |||
TMPY-00150 | IGF2/IGF-II Protein, Human, Recombinant | Human | P. pastoris (Yeast) |
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,... | |||
TMPJ-00529 | FABP6 Protein, Human, Recombinant (His) | Human | E. coli |
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine ... | |||
TMPY-02249 | FABP6 Protein, Human, Recombinant | Human | E. coli |
Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to t... | |||
TMPY-04765 | PKLR Protein, Human, Recombinant (His) | Human | E. coli |
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat... | |||
TMPY-03419 | SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) | Human,Mouse,Rat | Baculovirus Insect Cells |
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is... | |||
TMPY-01249 | Cathepsin V Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t... | |||
TMPY-04267 | MSH2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind... | |||
TMPJ-01083 | Serpin E2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea... | |||
TMPY-02100 | TEM7 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin fa... | |||
TMPY-01268 | SMYD3 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger... | |||
TMPY-00924 | SMAC Protein, Human, Recombinant (His) | Human | E. coli |
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p... |
カタログ番号 | 製品名 | ||
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L2194 | Anti-Colorectal Cancer Compound Library | 1545 compounds | |
1545 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening. | |||
L6740 | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | 382 compounds | |
A collection of 382 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies. | |||
L2192 | Anti-Pancreatic Cancer Compound Library | 2238 compounds | |
A unique collection of 2238 pancreatic cancer related compounds can be used in HTS and HCS; | |||
L4300 | Wnt/Hedgehog/Notch Compound Library | 237 compounds | |
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; |