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Search Results for " colorectal "

ターゲット

174

阻害剤

25

天然化合物

43

リコンビナントタンパク質

4

ライブラリー

カタログ番号 製品名 別名 ターゲット
T9151 Teplinovivint Wnt/beta-catenin
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
T9148 KA2507 HDAC
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
T9202 DDO-5936 HSP
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
T9810 TNIK-IN-5 Wnt/beta-catenin
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.
T9693 TBAP-001 Raf
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
T9963 MPT0B390 HDAC
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.
T60037 SR15006 DNA/RNA Synthesis
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).
T4985 Neticonazole Hydrochloride Antifungal
Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.
T1867 Otenaproxesul ATB 346 Apoptosis , COX
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
T24437 MCP110 MCP-110,MCP 110 Raf , Ras
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.
T11285 FIDAS-5 Others
FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.
T4435 E7820 ER68203-00 Integrin
E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
T2301 SB 202190 FHPI,SB202190 Apoptosis , p38 MAPK , Autophagy
SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...
T8545 FEN1-IN-4 FEN1 Inhibitor C2 Others
FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)
T22318 Taletrectinib DS-6051b,AB-106 Trk receptor , ROS , ROS Kinase
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.
T6255 Bromosporine Epigenetic Reader Domain , CDK
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T9696 β-catenin-IN-2 Wnt/beta-catenin
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T21294 Polmacoxib CG-100649,CG100649,CG 100649 COX , Carbonic Anhydrase
Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through...
T1290 Oxiconazole nitrate Ro 13-8996 Others , Antibiotic , Antifection , Antifungal
Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...
T6275 Obatoclax Mesylate Obatoclax,GX15-070 BCL , Parasite , Autophagy
Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.
T15396 GN44028 N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine HIF
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...
T0459 Sulindac Arthrocine,MK-231,Clinoril,Sulindac sulfoxide COX , Autophagy
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...
T2170 SKF-96365 hydrochloride SKF96365 Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T83641 HNPMI Apoptosis , EGFR
HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, may promote apoptosis, and may be used in the study of colorectal cancer.
T24642 YH-306 YH306,TRV055 acetate (25849-90-5 Free base) MMP , MMP , FAK , Rho , PI3K , Src
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
T6894 ML264 CID-51003603 DNA/RNA Synthesis , KLF
ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.
T27454 GSK2008607 Raf
GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
T27138 Declopramide OXI-104,IMO-B,3-Chloroprocainamide Apoptosis
Declopramide (OXI-104) is a novel chemosensitizer with antitumor activity that induces apoptosis and can be used to study colorectal cancer and inflammatory bowel disease.
T68051 Delequamine RS 15385-197 Adrenergic Receptor
Delequamine (RS 15385-197) is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.
TP2320 Pramlintide acetate(151126-32-8 free base) Others
Pramlintide acetate is a polypeptide analogue of human amylin. It serves as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.
T77407 Ensituximab NPC-1C,NEO-102,NEO-101
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer.
T62061 COX-2-IN-6 COX , Prostaglandin Receptor
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u...
T64066 CSF1R-IN-3 c-Fms , CSF-1R
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef...
T9901A-004 Labetuzumab IMMU-14,hMN-14,IMMU-100
Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with anticancer activity that inhibits tumor growth and is used in the study of thyroid and colorectal cancer (CRC).
T22429 SR18662 DNA/RNA Synthesis
SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis.
T77519 FC-116 FC116 Apoptosis , Microtubule Associated
FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation.
T77660 TINK-IN-1 Wnt/beta-catenin
TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.
T19802 B-Raf IN 11 Raf
B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.
T7598 Calcium N5-methyltetrahydrofolate NSC173328 Others , Antifolate
Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers
T9307 (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Others
SR18662 a.k.a. SR18662 is a KLF5 inhibitor based on the optimized structure of ML264. It inhibits the growth of colorectal cancer in vitro and in vivo.
T74698 RMC-6236 Ras
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
T2618 LGK974 LGK 974,LGK-974,NVP-LGK974,WNT974 Porcupine
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel...
T28740 SDZ-62-434 SDZ 62 434,SDZ62434 Platelet aggregation
SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity that inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells for the study of leukemia, human ...
T13810 Palmitoylcarnitine chloride Palmitoyl DL-carnitine chloride PKC
Palmitoylcarnitine chloride (Palmitoyl DL-carnitine chloride) is a mitochondrial fatty acid oxidation intermediate that mediates intralipid cardioprotection.Palmitoylcarnitine chloride eliminates colorectal cancer cell s...
T72068 SFI003 Apoptosis , ROS
SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen spec...
T21567L Cyclosomatostatin Acetate Cyclosomatostatin Acetate (84211-54-1 Free base) Somatostatin
Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell proliferation, ALDH+ cell population size, and sphere-formation in c...
T1307 Carmofur HCFU Nucleoside Antimetabolite/Analog , Virus Protease , SARS-CoV , DNA/RNA Synthesis
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
T79213 AZD4747 Ras
AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
T76792 Sibrotuzumab BIBH 1,Anti-Human FAP Recombinant Antibody Others
Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP).Sibrotuzumab is used in the study of colorectal cancer and non-small cell lung cancer.
T37170 N1-Acetylspermidine hydrochloride N1-Acetylspermidine (hydrochloride) Endogenous Metabolite
N1-Acetylspermidine hydrochloride is an acetyl derivative of spermidine. N1-Acetylspermidine hydrochloride is a substrate for the polyamine oxidase and selectively elevates the levels of which in human colorectal adenoca...

Compounds

Teplinovivint
T9151
Synonym:
Target: Wnt/beta-catenin
KA2507
T9148
Synonym:
Target: HDAC
DDO-5936
T9202
Synonym:
Target: HSP
TNIK-IN-5
T9810
Synonym:
Target: Wnt/beta-catenin
TBAP-001
T9693
Synonym:
Target: Raf
MPT0B390
T9963
Synonym:
Target: HDAC
SR15006
T60037
Synonym:
Target: DNA/RNA Synthesis
Neticonazole Hydrochloride
T4985
Synonym:
Target: Antifungal
Otenaproxesul
T1867
Synonym: ATB 346
Target: Apoptosis, COX
MCP110
T24437
Synonym: MCP-110,MCP 110
Target: Raf, Ras
FIDAS-5
T11285
Synonym:
Target: Others
E7820
T4435
Synonym: ER68203-00
Target: Integrin
SB 202190
T2301
Synonym: FHPI,SB202190
Target: Apoptosis, p38 MAPK, Autophagy
FEN1-IN-4
T8545
Synonym: FEN1 Inhibitor C2
Target: Others
Taletrectinib
T22318
Synonym: DS-6051b,AB-106
Target: Trk receptor, ROS, ROS Kinase
Bromosporine
T6255
Synonym:
Target: Epigenetic Reader Domain, CDK
β-catenin-IN-2
T9696
Synonym:
Target: Wnt/beta-catenin
Polmacoxib
T21294
Synonym: CG-100649,CG100649,CG 100649
Target: COX, Carbonic Anhydrase
Oxiconazole nitrate
T1290
Synonym: Ro 13-8996
Target: Others, Antibiotic, Antifection, Antifungal
Obatoclax Mesylate
T6275
Synonym: Obatoclax,GX15-070
Target: BCL, Parasite, Autophagy
GN44028
T15396
Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Target: HIF
Sulindac
T0459
Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide
Target: COX, Autophagy
SKF-96365 hydrochloride
T2170
Synonym: SKF96365
Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy
HNPMI
T83641
Synonym:
Target: Apoptosis, EGFR
YH-306
T24642
Synonym: YH306,TRV055 acetate (25849-90-5 Free base)
Target: MMP, MMP, FAK, Rho, PI3K, Src
ML264
T6894
Synonym: CID-51003603
Target: DNA/RNA Synthesis, KLF
GSK2008607
T27454
Synonym:
Target: Raf
Declopramide
T27138
Synonym: OXI-104,IMO-B,3-Chloroprocainamide
Target: Apoptosis
Delequamine
T68051
Synonym: RS 15385-197
Target: Adrenergic Receptor
Pramlintide acetate(151126-32-8 free base)
TP2320
Synonym:
Target: Others
Ensituximab
T77407
Synonym: NPC-1C,NEO-102,NEO-101
Target:
COX-2-IN-6
T62061
Synonym:
Target: COX, Prostaglandin Receptor
CSF1R-IN-3
T64066
Synonym:
Target: c-Fms, CSF-1R
Labetuzumab
T9901A-004
Synonym: IMMU-14,hMN-14,IMMU-100
Target:
SR18662
T22429
Synonym:
Target: DNA/RNA Synthesis
FC-116
T77519
Synonym: FC116
Target: Apoptosis, Microtubule Associated
TINK-IN-1
T77660
Synonym:
Target: Wnt/beta-catenin
B-Raf IN 11
T19802
Synonym:
Target: Raf
Calcium N5-methyltetrahydrofolate
T7598
Synonym: NSC173328
Target: Others, Antifolate
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
T9307
Synonym:
Target: Others
RMC-6236
T74698
Synonym:
Target: Ras
LGK974
T2618
Synonym: LGK 974,LGK-974,NVP-LGK974,WNT974
Target: Porcupine
SDZ-62-434
T28740
Synonym: SDZ 62 434,SDZ62434
Target: Platelet aggregation
Palmitoylcarnitine chloride
T13810
Synonym: Palmitoyl DL-carnitine chloride
Target: PKC
SFI003
T72068
Synonym:
Target: Apoptosis, ROS
Cyclosomatostatin Acetate
T21567L
Synonym: Cyclosomatostatin Acetate (84211-54-1 Free base)
Target: Somatostatin
Carmofur
T1307
Synonym: HCFU
Target: Nucleoside Antimetabolite/Analog, Virus Protease, SARS-CoV, DNA/RNA Synthesis
AZD4747
T79213
Synonym:
Target: Ras
Sibrotuzumab
T76792
Synonym: BIBH 1,Anti-Human FAP Recombinant Antibody
Target: Others
N1-Acetylspermidine hydrochloride
T37170
Synonym: N1-Acetylspermidine (hydrochloride)
Target: Endogenous Metabolite
1 2 3 4
カタログ番号 製品名 別名 ターゲット
T3055 Liensinine Perchlorate Apoptosis , Others
Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
TN1305 Ethoxysanguinarine 6-Ethoxydihydrosanguinarine Apoptosis , AChR
Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-...
TN1465 Cannabigerol NOS , 5-HT Receptor , ROS
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur...
T2988 (-)-Epigallocatechin Gallate Epigallocatechol Gallate,EGCG Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
T4456 N4-Acetylcytidine N-Acetylcytidine Others , Endogenous Metabolite
N4-Acetylcytidine (N-Acetylcytidine) is a modified nucleoside. N4-acetylcytidine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological mark...
TQ0193 N2,N2-Dimethylguanosine Endogenous Metabolite
N2,N2-Dimethylguanosine is an urinary nucleoside. The mean levels of urinary N2,N2-Dimethylguanosine in patients with colorectal cancer are significantly higher than those in patients with intestinal villous adenoma or h...
T8166 Pennogenin 3-O-beta-chacotrioside Autophagy
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Be...
TJP2872 Acevaltrate Acevaltratum,Acetoxyvaltrate ATPase , Others
1. Acevaltrate (Acevaltratum) displays high cytotoxicity against GLC(4), a human small-cell lung cancer cell line, and against COLO 320, a human colorectal cancer cell line, with IC50 values of 1-6 uM.
T3391 Corosolic acid Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid FAK , Autophagy
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci...
T6599 N6-methyladenosine N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A Others , Influenza Virus , Endogenous Metabolite
N6-methyladenosine (NSC-29409) is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological ma...
TN1237 3-O-Methylgallic acid 3,4-Dihydroxy-5-methoxybenzoic acid Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...
T36715 Tetrac Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid Apoptosis , EGFR
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...
T2938 (E/Z)-Polydatin Polydatin,(E/Z)-Piceid Phospholipase
(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be det...
T8053 N-Acetyl-L-arginine Ac-Arg-OH Endogenous Metabolite
N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-...
TN6617 Malvidin-3-O-arabinoside chloride
Malvidin-3-O-arabinoside chloride has antioxidant activity.It has potential preventive effect in colorectal diseases.
TN3812 Dehydrovomifoliol AChR
Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three h...
TN2726 Jatrophane 5 P-gp
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
TN1324 6-O-Nicotinoylscutebarbatine G Others
6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in th...
T3425 Polyphyllin G Polyphyllin VII,Polyphyllin VII,Y-0166 Others
Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocel...
TN3686 Coccinic acid Others
Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual ...
T79933 (−)-N-Hydroxyapiosporamide NHAP NF-κB
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has potential applications in colorectal cancer (CRC) research [1...
TMA0291 Dehydroglyasperin D GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit...
T36815 Chevalone C
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). ...
TN2727 Jatrophane 2 P-gp , Antifection
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Ja...
TN1694 Gliotoxin Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

天然物製品

Liensinine Perchlorate
T3055
Synonym:
Target: Apoptosis, Others
Ethoxysanguinarine
TN1305
Synonym: 6-Ethoxydihydrosanguinarine
Target: Apoptosis, AChR
Cannabigerol
TN1465
Synonym:
Target: NOS, 5-HT Receptor, ROS
(-)-Epigallocatechin Gallate
T2988
Synonym: Epigallocatechol Gallate,EGCG
Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy
N4-Acetylcytidine
T4456
Synonym: N-Acetylcytidine
Target: Others, Endogenous Metabolite
N2,N2-Dimethylguanosine
TQ0193
Synonym:
Target: Endogenous Metabolite
Pennogenin 3-O-beta-chacotrioside
T8166
Synonym:
Target: Autophagy
Acevaltrate
TJP2872
Synonym: Acevaltratum,Acetoxyvaltrate
Target: ATPase, Others
Corosolic acid
T3391
Synonym: Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid
Target: FAK, Autophagy
N6-methyladenosine
T6599
Synonym: N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A
Target: Others, Influenza Virus, Endogenous Metabolite
3-O-Methylgallic acid
TN1237
Synonym: 3,4-Dihydroxy-5-methoxybenzoic acid
Target: Apoptosis, NF-κB, OCT, DNA/RNA Synthesis, STAT
Tetrac
T36715
Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid
Target: Apoptosis, EGFR
(E/Z)-Polydatin
T2938
Synonym: Polydatin,(E/Z)-Piceid
Target: Phospholipase
N-Acetyl-L-arginine
T8053
Synonym: Ac-Arg-OH
Target: Endogenous Metabolite
Malvidin-3-O-arabinoside chloride
TN6617
Synonym:
Target:
Dehydrovomifoliol
TN3812
Synonym:
Target: AChR
Jatrophane 5
TN2726
Synonym:
Target: P-gp
6-O-Nicotinoylscutebarbatine G
TN1324
Synonym:
Target: Others
Polyphyllin G
T3425
Synonym: Polyphyllin VII,Polyphyllin VII,Y-0166
Target: Others
Coccinic acid
TN3686
Synonym:
Target: Others
(−)-N-Hydroxyapiosporamide
T79933
Synonym: NHAP
Target: NF-κB
Dehydroglyasperin D
TMA0291
Synonym:
Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK
Chevalone C
T36815
Synonym:
Target:
Jatrophane 2
TN2727
Synonym:
Target: P-gp, Antifection
Gliotoxin
TN1694
Synonym:
Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-04153 RNF43 Protein, Human, Recombinant (His) Human HEK293 Cells
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-02575 PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
TMPY-02292 IGSF11 Protein, Human, Recombinant (His) Human HEK293 Cells
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins sh...
TMPY-00365 GALNT7 Protein, Human, Recombinant (His) Human HEK293 Cells
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either ...
TMPY-01442 DMBT1 Protein, Human, Recombinant (His) Human HEK293 Cells
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d...
TMPY-04149 RNF43 Protein, Human, Recombinant (hFc) Human HEK293 Cells
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPH-02218 JUN Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali...
TMPH-02219 JUN Protein, Human, Recombinant (His & Myc) Human E. coli
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali...
TMPK-01131 Neogenin Protein, Human, Recombinant (hFc) Human HEK293 Cells
Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axo...
TMPY-02572 TXNDC17 Protein, Human, Recombinant Human E. coli
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa...
TMPJ-00796 Serpin E2 Protein, Human, Recombinant (His) Human HEK293 Cells
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal panc...
TMPK-01323 CEACAM1 Protein, Canine, Recombinant (His) Canine HEK293 Cells
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1...
TMPK-00869 CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His) Mouse HEK293 Cells
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1...
TMPK-00898 EphB3 Protein, Human, Recombinant (His) Human HEK293 Cells
Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is co...
TMPY-00497 ZG16 Protein, Human, Recombinant (mFc) Human HEK293 Cells
Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. Proteomic analyses of mucus have identified the lectin-like protein ZG16 as an abundant mucus co...
TMPY-05168 Syndecan-2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde...
TMPY-04249 Syndecan-2 Protein, Human, Recombinant (His) Human HEK293 Cells
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde...
TMPY-03673 REG3B Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its exp...
TMPK-01306 CDH3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPK-00800 CDH3 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPJ-01155 PDCD4 Protein, Human, Recombinant (His) Human E. coli
Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation...
TMPY-03859 DHRS9 Protein, Human, Recombinant (His) Human E. coli
Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic bioma...
TMPK-00851 CDH3 Protein, Human, Recombinant (aa 108-654, His) Human HEK293 Cells
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPK-01332 LY6G6D Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPK-00753 LY6G6D Protein, Human, Recombinant (His) Human HEK293 Cells
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPH-01699 SMAD2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in t...
TMPY-02046 PFDN1 Protein, Mouse, Recombinant (His) Mouse E. coli
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPY-03989 PFDN1 Protein, Human, Recombinant (His) Human E. coli
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPY-03329 DPEP1 Protein, Human, Recombinant (His) Human HEK293 Cells
Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl...
TMPK-00752 LY6G6D Protein, Human, Recombinant (hFc) Human HEK293 Cells
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPH-01048 CEACAM5 Protein, Human, Recombinant (E398K, His) Human HEK293 Cells
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion mo...
TMPK-00754 LY6G6D Protein, Human, Recombinant (His & Strep-II) Human HEK293 Cells
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPY-00150 IGF2/IGF-II Protein, Human, Recombinant Human P. pastoris (Yeast)
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,...
TMPJ-00529 FABP6 Protein, Human, Recombinant (His) Human E. coli
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine ...
TMPY-02249 FABP6 Protein, Human, Recombinant Human E. coli
Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to t...
TMPY-04765 PKLR Protein, Human, Recombinant (His) Human E. coli
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat...
TMPY-03419 SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) Human,Mouse,Rat Baculovirus Insect Cells
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is...
TMPY-01249 Cathepsin V Protein, Human, Recombinant (His) Human HEK293 Cells
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t...
TMPY-04267 MSH2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind...
TMPJ-01083 Serpin E2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea...
TMPY-02100 TEM7 Protein, Human, Recombinant (His) Human HEK293 Cells
Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin fa...
TMPY-01268 SMYD3 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger...
TMPY-00924 SMAC Protein, Human, Recombinant (His) Human E. coli
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p...
RNF43 Protein, Human, Recombinant (His)
TMPY-04153
Species: Human
Expression System: HEK293 Cells
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
TMPY-02575
Species: Human
Expression System: Baculovirus Insect Cells
IGSF11 Protein, Human, Recombinant (His)
TMPY-02292
Species: Human
Expression System: HEK293 Cells
GALNT7 Protein, Human, Recombinant (His)
TMPY-00365
Species: Human
Expression System: HEK293 Cells
DMBT1 Protein, Human, Recombinant (His)
TMPY-01442
Species: Human
Expression System: HEK293 Cells
RNF43 Protein, Human, Recombinant (hFc)
TMPY-04149
Species: Human
Expression System: HEK293 Cells
JUN Protein, Human, Recombinant (His)
TMPH-02218
Species: Human
Expression System: Baculovirus Insect Cells
JUN Protein, Human, Recombinant (His & Myc)
TMPH-02219
Species: Human
Expression System: E. coli
Neogenin Protein, Human, Recombinant (hFc)
TMPK-01131
Species: Human
Expression System: HEK293 Cells
TXNDC17 Protein, Human, Recombinant
TMPY-02572
Species: Human
Expression System: E. coli
Serpin E2 Protein, Human, Recombinant (His)
TMPJ-00796
Species: Human
Expression System: HEK293 Cells
CEACAM1 Protein, Canine, Recombinant (His)
TMPK-01323
Species: Canine
Expression System: HEK293 Cells
CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His)
TMPK-00869
Species: Mouse
Expression System: HEK293 Cells
EphB3 Protein, Human, Recombinant (His)
TMPK-00898
Species: Human
Expression System: HEK293 Cells
ZG16 Protein, Human, Recombinant (mFc)
TMPY-00497
Species: Human
Expression System: HEK293 Cells
Syndecan-2 Protein, Mouse, Recombinant (His)
TMPY-05168
Species: Mouse
Expression System: HEK293 Cells
Syndecan-2 Protein, Human, Recombinant (His)
TMPY-04249
Species: Human
Expression System: HEK293 Cells
REG3B Protein, Mouse, Recombinant (His)
TMPY-03673
Species: Mouse
Expression System: HEK293 Cells
CDH3 Protein, Cynomolgus, Recombinant (His)
TMPK-01306
Species: Cynomolgus
Expression System: HEK293 Cells
CDH3 Protein, Mouse, Recombinant (His)
TMPK-00800
Species: Mouse
Expression System: HEK293 Cells
PDCD4 Protein, Human, Recombinant (His)
TMPJ-01155
Species: Human
Expression System: E. coli
DHRS9 Protein, Human, Recombinant (His)
TMPY-03859
Species: Human
Expression System: E. coli
CDH3 Protein, Human, Recombinant (aa 108-654, His)
TMPK-00851
Species: Human
Expression System: HEK293 Cells
LY6G6D Protein, Cynomolgus, Recombinant (His)
TMPK-01332
Species: Cynomolgus
Expression System: HEK293 Cells
LY6G6D Protein, Human, Recombinant (His)
TMPK-00753
Species: Human
Expression System: HEK293 Cells
SMAD2 Protein, Human, Recombinant (His & SUMO)
TMPH-01699
Species: Human
Expression System: E. coli
PFDN1 Protein, Mouse, Recombinant (His)
TMPY-02046
Species: Mouse
Expression System: E. coli
PFDN1 Protein, Human, Recombinant (His)
TMPY-03989
Species: Human
Expression System: E. coli
DPEP1 Protein, Human, Recombinant (His)
TMPY-03329
Species: Human
Expression System: HEK293 Cells
LY6G6D Protein, Human, Recombinant (hFc)
TMPK-00752
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (E398K, His)
TMPH-01048
Species: Human
Expression System: HEK293 Cells
LY6G6D Protein, Human, Recombinant (His & Strep-II)
TMPK-00754
Species: Human
Expression System: HEK293 Cells
IGF2/IGF-II Protein, Human, Recombinant
TMPY-00150
Species: Human
Expression System: P. pastoris (Yeast)
FABP6 Protein, Human, Recombinant (His)
TMPJ-00529
Species: Human
Expression System: E. coli
FABP6 Protein, Human, Recombinant
TMPY-02249
Species: Human
Expression System: E. coli
PKLR Protein, Human, Recombinant (His)
TMPY-04765
Species: Human
Expression System: E. coli
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
TMPY-03419
Species: Human,Mouse,Rat
Expression System: Baculovirus Insect Cells
Cathepsin V Protein, Human, Recombinant (His)
TMPY-01249
Species: Human
Expression System: HEK293 Cells
MSH2 Protein, Human, Recombinant (His & GST)
TMPY-04267
Species: Human
Expression System: Baculovirus Insect Cells
Serpin E2 Protein, Mouse, Recombinant (His)
TMPJ-01083
Species: Mouse
Expression System: HEK293 Cells
TEM7 Protein, Human, Recombinant (His)
TMPY-02100
Species: Human
Expression System: HEK293 Cells
SMYD3 Protein, Human, Recombinant (GST)
TMPY-01268
Species: Human
Expression System: Baculovirus Insect Cells
SMAC Protein, Human, Recombinant (His)
TMPY-00924
Species: Human
Expression System: E. coli
カタログ番号 製品名
L2194 Anti-Colorectal Cancer Compound Library

1545 compounds
1545 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L6740 Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library

382 compounds
A collection of 382 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies.
L2192 Anti-Pancreatic Cancer Compound Library

2238 compounds
A unique collection of 2238 pancreatic cancer related compounds can be used in HTS and HCS;
L4300 Wnt/Hedgehog/Notch Compound Library

237 compounds
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;