Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fulacimstat (BAY1142524) (BAY1142524) is a chymase inhibitor, with IC50s of 3, 4 nM for hamster and human chymase enzyme, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 31,000 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 95,000 | |||
25 mg | 在庫あり | ¥ 159,000 | |||
50 mg | 在庫あり | ¥ 226,000 | |||
100 mg | 在庫あり | ¥ 305,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,500 |
説明 | Fulacimstat (BAY1142524) (BAY1142524) is a chymase inhibitor, with IC50s of 3, 4 nM for hamster and human chymase enzyme, respectively. |
ターゲット&IC50 | Hamster chymase enzyme:3 nM, Chymase:4 nM |
In vivo | Isoprenaline induces cardiac fibrosis (24.4%) in hamsters, which is reduced dose-dependently by Fulacimstat (16.4%, 12.4%, 10.9% at 1, 3 and 10 mg/kg respectively). Four weeks after MI, hamster hearts show increased end-diastolic pressure and reduce contractility and relaxation. Compared to placebo (19.3±2 mmHg), Fulacimstat at 10 mg/kg reduces significantly the end-diastolic pressure (13.2±1.4 mmHg) without any effects on blood pressure or heart rate. Moreover, treatment with Fulacimstat reduces the fibrotic area and improves the cardiac response to adrenergic stimulation [1]. |
別名 | BAY1142524 |
分子量 | 487.38 |
分子式 | C23H16F3N3O6 |
CAS No. | 1488354-15-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (10.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Fulacimstat 1488354-15-9 Others inhibit BAY1142524 Inhibitor BAY 1142524 BAY-1142524 inhibitor