Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
説明 | GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) . |
ターゲット&IC50 | TBK1:6.8 (pIC50) |
In vitro | In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING. |
分子量 | 520.33 |
分子式 | C17H17BrF3N7O2S |
CAS No. | 2361659-62-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 100 mg/mL (192.19 mM)
You can also refer to dose conversion for different animals. 詳細
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GSK8612 2361659-62-1 NF-Κb IκB/IKK Inhibitor GSK 8612 IKK I kappa B kinase GSK-8612 inhibit IκB kinase inhibitor