Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 95,000 |
5 mg | 在庫あり | ¥ 282,500 |
10 mg | 在庫あり | ¥ 385,500 |
25 mg | 在庫あり | ¥ 571,500 |
50 mg | 在庫あり | ¥ 771,500 |
100 mg | 在庫あり | ¥ 1,040,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 310,000 |
説明 | Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation. |
In vitro | Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis.?Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities.?Gedunin treatment also inhibited sonic hedgehog signaling pathways.?Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling.?The anti-cancer effect of gedunin was further validated using xenograft mouse model. |
分子量 | 482.57 |
分子式 | C28H34O7 |
CAS No. | 2753-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (124.33 mM)
You can also refer to dose conversion for different animals. 詳細
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