Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).
説明 | Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). |
ターゲット&IC50 | EP4:35 nM |
In vivo | Grapiprant (0-50 mg/kg; p.o; every 24 hours; for 9 months; beagles) is safe for dogs by long-term oral administration [2]. |
動物実験 | Animal Model: 36 beagles of both sexes (9-month-old). Dosage: 0 mg/kg, 1 mg/kg, 6 mg/kg, or 50 mg/kg. Administration: Oral administration; every 24 hours; for 9 months [2] |
別名 | AAT-007, RQ-00000007, CJ-023423 |
分子量 | 491.61 |
分子式 | C26H29N5O3S |
CAS No. | 415903-37-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (97.64 mM)
You can also refer to dose conversion for different animals. 詳細
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Grapiprant 415903-37-6 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor AAT 007 AAT007 Inhibitor AAT-007 CJ 023423 RQ 00000007 RQ-00000007 CJ023423 inhibit RQ00000007 CJ-023423 inhibitor