Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
説明 | H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity. |
ターゲット&IC50 | CPS1:1.4 μM (ki), CPS1:1.5 μM |
In vitro | H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. The half-life of H3B-120 is only 40 min. H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase). |
分子量 | 372.48 |
分子式 | C19H24N4O2S |
CAS No. | 2194903-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62 mg/mL (166.45 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
H3B-120 2194903-42-7 Membrane transporter/Ion channel Others Potassium Channel KcsA H3B 120 carbamoyl H3B120 inhibit Inhibitor anti-cancer phosphate synthetase CPS1 H-3B-120 inhibitor