Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 31,000 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 104,500 | |||
25 mg | 在庫あり | ¥ 173,000 | |||
50 mg | 在庫あり | ¥ 243,500 | |||
100 mg | 在庫あり | ¥ 328,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,000 |
説明 | HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM). |
ターゲット&IC50 | TRPC5 (human):9.3 nM, TRPC4 (human):46 nM |
In vitro | HC-070 inhibits hTRPC5 currents activated via muscarinic type 1 (IC50 = 2.0 nM) and suppresses hTRPC4 currents via muscarinic type 2 (IC50 = 0.49 nM). In whole-cell manual patch clamp, HC-070 inhibits lanthanum-activated hTRPC5-, mTRPC5-, rTRPC5-mediated currents (IC50s of 0.52 nM, 0.55 nM, and 0.32 nM). In the amygdala slices, HC-070 (20 nM) decreases CCK-4-evoked neuronal activity. HC-070 weakly inhibits TRPC3 (IC50 = 1 μM) and blocks M2R-activated human TRPC1/TRPC4 channels (IC50 = 1.3 nM) and La3+- and M1R-activated human TRPC1/5 channels (IC50 = 1.4 nM and 4.4 nM)[1]. |
In vivo | HC-070 (1 mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. HC-070 (1 mg/kg, p.o.) affects mice with increased CCK-4-evoked anxiety. HC-070 (0.3-3 mg/kg, p.o.) causes a reduction of anxiety in a standard EPM. HC-070 (0.3-10 mg/kg, p.o.) reduces the time of immobility in a tail suspension test without impacting locomotor activity in mice. HC-070 (1-10 mg/kg, p.o.) reduces marble-burying behavior[1]. |
別名 | HC 070 |
分子量 | 475.32 |
分子式 | C22H20Cl2N4O4 |
CAS No. | 1628291-95-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (105.2 mM)
You can also refer to dose conversion for different animals. 詳細
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HC-070 1628291-95-1 Membrane transporter/Ion channel TRP/TRPV Channel HC070 HC 070 Inhibitor inhibitor inhibit