Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 68,500 | |||
100 mg | 在庫あり | ¥ 104,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,500 |
説明 | HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model |
In vitro | HS-1793 was found to inhibit hypoxia (1.0% oxygen)-induced HIF-1α expression at the protein level, and its inhibitory effect was more potent than that of resveratrol in MCF-7 and MDA-MB-231 breast cancer cells.?Furthermore, HS-1793 reduced the secretion and mRNA expression of vascular endothelial growth factor (VEGF), a key mediator of HIF-1-driven angiogenesis, without affecting cell viability. |
In vivo | HS-1793 significantly suppressed the growth of breast cancer tumor xenografts, without any apparent toxicity.?Additionally, decreases in Ki-67, a proliferation index marker, and CD31, a biomarker of microvessel density, were observed in the tumor tissue.?Expression of HIF-1 and VEGF was also downregulated in xenograft tumors treated with HS-1793.?These in vivo results reinforce the improved anticancer activity of HS-1793 when compared with that of resveratrol.?Overall, the present study suggests that the synthetic resveratrol analogue HS-1793 is a potent antitumor agent that inhibits tumor growth via the regulation of HIF-1, and demonstrates significant therapeutic potential for solid cancers. |
分子量 | 252.26 |
分子式 | C16H12O3 |
CAS No. | 927885-00-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (89.19 mM)
You can also refer to dose conversion for different animals. 詳細
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HS-1793 927885-00-5 Others HIF-1α Inhibitor MCF-7 breast cancer inhibit ERK HS1793 HCT116 resveratrol VEGF Apoptosis Akt colon cancer HS 1793 inhibitor