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カタログ番号 | 製品名 | 別名 | ターゲット |
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T61349 | HIF-1α-IN-2 | HIF | |
HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-dependent manner and inhibits cell migration. | |||
T3494 | LW6 | HIF-1α inhibitor,CAY10585,LW8 | Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF |
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor. | |||
T36711 | FM19G11 | FM19G11,HIF-1alpha/2alpha Inhibitor | HIF |
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay). | |||
T21653 | 1,4-DPCA | HIF/HIF Prolyl-Hydroxylase | |
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH). | |||
T82198 | HIF-1α-IN-6 | HIF/HIF Prolyl-Hydroxylase | |
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively. It suppresses HIF-1α expression through the reduction of HIF-1α ... | |||
T60524 | HIF-1α-IN-4 | ||
HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1]. | |||
T60532 | HIF-1α-IN-5 | ||
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has... | |||
T61161 | HIF-1α-IN-3 | ||
HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1]. | |||
T71661 | HIF-1α inhibitor-1 | ||
HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor. | |||
T78123 | HIF-1α-IN-2 hydrochloride | HIF/HIF Prolyl-Hydroxylase | |
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells. It effectively suppresses HIF-1α expression by... | |||
T0692 | Allopurinol | Zyloric,Zyloprim,Lopurin | ROS , Xanthine Oxidase |
Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor. | |||
T8973 | HS-1793 | Others | |
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model | |||
T71659 | Indacaterol acetate | ||
Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T6376 | Allopurinol Sodium | Allopurinol sodium salt,Sodium allopurinol | ROS |
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. | |||
T19832 | Acriflavine Hydrochloride | Acriflavine HCl | HIF |
Acriflavine Hydrochloride (Acriflavine HCl) is a HIF-1α inhibitor. It acts by targeting HIF-1α-mediated pathways and decreasing the level of PGK1, VEGF, and HIF-1α in vitro and in vivo. | |||
T13398 | ZINC13466751 | HIF | |
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM). | |||
T15396 | GN44028 | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine | HIF |
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H... | |||
T67767 | HIF-1 inhibitor-4 | HIF-1 inhibitor-4 | HIF |
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level. | |||
T5537 | IDF-11774 | HIF/HIF Prolyl-Hydroxylase , HIF | |
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM). | |||
T17009 | TC-S 7009 | HIF | |
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene e... | |||
T20974 | IR-780 Iodide | IR 780 iodide | Others |
IR-780 Iodide (IR 780 iodide), a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity. | |||
T1637 | Deferoxamine Mesylate | desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM | Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy |
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i... | |||
T29106 | VH032 | VH-032,VH 032 | Ligand for E3 Ligase |
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a l... | |||
T6961 | PX-478 | PX-478 2HCl | HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy |
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di... | |||
T67836 | AT-533 | HSP , HSV | |
AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i... | |||
T1939 | DMOG | Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine | HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy |
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase. | |||
T4381 | Lificiguat | YC-1 | Others , Guanylate cyclase , HIF |
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). | |||
T2309 | Ganetespib | STA-9090 | Apoptosis , HSP , HIF |
Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. | |||
T124358 | Deferoxamine | Deferoxamine B,Desferrioxamine B | Apoptosis , Antioxidant , HIF , Autophagy |
Deferoxamine(Desferrioxamine B) is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may imp... | |||
T2283 | PX-12 | IV-2,PX12 | Thioredoxin |
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr... | |||
T0153 | Oltipraz | NSC 347901,RP 35972 | HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF |
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin... | |||
T24148 | HPCG | ||
HPCG is an inhibitor of HIF-1α prolyl hydroxylase. | |||
T6804 | Chetomin | Chaetomin,NSC289491,BRN0077366 | Apoptosis , HSP , HIF |
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. | |||
T60398 | Dimethyl-bisphenol A | ||
Dimethyl-bisphenol A (DMBPA) is the potent inhibitor of HIF-1α. Dimethyl-Bisphenol A promotes degradation of HIF-1α protein by dissociating Hsp90 from HIF-1α. Dimethyl-bisphenol A can decrease the expression of Vegfa mRN... | |||
T70788 | KST012174 HCl | ||
KST012174 is a HIF-1α inhibitor. KST012174 involves in the HIF-1α/p300 protein−protein interaction. | |||
T27866 | LXY6090 | LXY 6090,LXY-6090 | |
LXY6090 is a HIF-1 inhibitor. LXY6090 inhibited the activity of HIF-1 and downregulated the protein level of HIF-1α in breast cancer cells. LXY6090 showed in vivo anticancer efficacy by decreasing the HIF-1α expression i... | |||
T23988 | DHPCG | ||
DHPCG is an inhibitor of HIF-1α prolyl hydroxylase. | |||
T82595 | DEALA-Hyp-YIPD | ||
DEALA-Hyp-YIPD, an HIF-1α peptide inhibitor, impedes the VHL/HIF-1α interaction with an half-maximal inhibitory concentration (IC50) of 0.91 μM and a dissociation constant (Kd) of 180 nM [1]. | |||
T68718 | 103D5R | ||
103D5R is a novel selective inhibitor of hif-1α, markedly decreasing hif-1α protein levels induced by hypoxia or cobaltous ions in a dose- and time-dependent manner | |||
T75943 | TAT-cyclo-CLLFVY TFA | ||
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor specifically targeting HIF-1 heterodimerization to mitigate hypoxia signaling within cancer cells. It effectively disrupts the protein-protein interaction between HIF-1α... | |||
TP2046 | TAT-cyclo-CLLFVY | ||
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi... | |||
T10258 | AFP464 free base | NSC710464 free base | HIF |
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator. | |||
T74530 | GEM-5 | ||
GEM-5, a gemcitabine-based conjugate incorporating a HIF-1α inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF-1α expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and c... | |||
T60413 | HIF-IN-1 | HIF | |
HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation. | |||
T15234 | ENMD-1198 | IRC 110160,ENMD-119,ENMD 1198 | HIF , STAT |
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells. | |||
T63035 | Izilendustat hydrochloride | ||
Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2). Potential for HIF-1α-related diseases (including ... | |||
T61442 | HIF-1/2α-IN-1 | ||
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea... | |||
T79720 | VHL-IN-1 | HIF/HIF Prolyl-Hydroxylase | |
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for appli... | |||
T71116 | MPT0B098 | ||
MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values r... | |||
T26573 | AG311 | AG 311,AG-311 | |
AG311 is an inhibitor of complex I and hypoxia-induced HIF-1α stabilization. In vitro, AG311 induces rapid necrosis in numerous cancer cell lines. Within minutes, exposure to AG311 also results in mitochondrial depolariz... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T3860 | Isoliquiritin apioside | MMP , p38 MAPK , NF-κB | |
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse... | |||
T11589 | Hydroxycitric acid tripotassium hydrate | Potassium citrate monohydrate | ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr... | |||
T0256 | Citric acid trilithium salt tetrahydrate | Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate | Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways... | |||
T1123 | Camptothecin | NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT | Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal |
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis. | |||
TN1480 | Cephaeline | Virus Protease , Influenza Virus , HIF | |
Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis. | |||
T5740 | 25(R,S)-Ruscogenin | (25RS)-Ruscogenin | Others , HIF |
25(R,S)-Ruscogenin is a natual product. | |||
T6S0071 | Fraxinellone | HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1 | |
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding... | |||
T3S2344 | β,β-Dimethylacrylshikonin | Dimethylacrylshikonin,β, β-Dimethylacrylshikonin | ERK , HIF/HIF Prolyl-Hydroxylase |
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant... | |||
T3816 | Velutin | NF-κB , HIF/HIF Prolyl-Hydroxylase | |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ... | |||
T75487 | 7-Hydroxyneolamellarin A | ||
7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α). It effectively reduces the accumulation of HIF-1α protein and suppresses ... | |||
T36749 | Herboxidiene | ||
Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin... | |||
T36439 | Gramicidin A | Antibacterial , HIF , Parasite | |
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01709 | HIF-1 alpha Protein, Human, Recombinant (His) | Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (... | |||
TMPY-00585 | Annexin A8 Protein, Human, Recombinant (His) | Human | E. coli |
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA... | |||
TMPY-01576 | Artemin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored... |
カタログ番号 | 製品名 | ||
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L8500 | HIF-1 Signaling Pathway Compound Library | 1336 compounds | |
A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |