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Search Results for " HIF-1α "

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60

阻害剤

12

天然化合物

3

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T61349 HIF--IN-2 HIF
HIF--IN-2 is a novel and highly potent HIF- inhibitor with anticancer and antitumor activity that inhibits the expression of HIF- and VEGF in a dose-dependent manner and inhibits cell migration.
T3494 LW6 HIF- inhibitor,CAY10585,LW8 Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF
LW6 (HIF- inhibitor) is a novel HIF-1 inhibitor.
T36711 FM19G11 FM19G11,HIF-1alpha/2alpha Inhibitor HIF
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
T21653 1,4-DPCA HIF/HIF Prolyl-Hydroxylase
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
T82198 HIF--IN-6 HIF/HIF Prolyl-Hydroxylase
HIF--IN-6 (compound 3s) is a potent inhibitor of HIF-, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively. It suppresses HIF- expression through the reduction of HIF- ...
T60524 HIF--IN-4
HIF--IN-4 is an inhibitor of HIF- with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF--IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1].
T60532 HIF--IN-5
HIF--IN-5 is an inhibitor of HIF- with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF--IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF--IN-5 has...
T61161 HIF--IN-3
HIF--IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-. It exhibits potent antiestrogenic activity [1].
T71661 HIF- inhibitor-1
HIF- inhibitor-1 is a HIF-1 alpha inhibitor.
T78123 HIF--IN-2 hydrochloride HIF/HIF Prolyl-Hydroxylase
HIF--IN-2 hydrochloride is a potent HIF- inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells. It effectively suppresses HIF- expression by...
T0692 Allopurinol Zyloric,Zyloprim,Lopurin ROS , Xanthine Oxidase
Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
T8973 HS-1793 Others
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model
T71659 Indacaterol acetate
Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist.
T6376 Allopurinol Sodium Allopurinol sodium salt,Sodium allopurinol ROS
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
T19832 Acriflavine Hydrochloride Acriflavine HCl HIF
Acriflavine Hydrochloride (Acriflavine HCl) is a HIF- inhibitor. It acts by targeting HIF--mediated pathways and decreasing the level of PGK1, VEGF, and HIF- in vitro and in vivo.
T13398 ZINC13466751 HIF
ZINC13466751 is a potent HIF-/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM).
T15396 GN44028 N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine HIF
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF- transcriptional activity. H...
T67767 HIF-1 inhibitor-4 HIF-1 inhibitor-4 HIF
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF- protein level without affecting its mRNA level.
T5537 IDF-11774 HIF/HIF Prolyl-Hydroxylase , HIF
IDF-11774 is a HIF-1 inhibitor.It reduces hif- HRE luciferase activity (IC50 = 3.65 μM).
T17009 TC-S 7009 HIF
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF- (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene e...
T20974 IR-780 Iodide IR 780 iodide Others
IR-780 Iodide (IR 780 iodide), a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF/glycolysis dependent mitochondrial transporter ABCB10's activity.
T1637 Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF- levels and i...
T29106 VH032 VH-032,VH 032 Ligand for E3 Ligase
VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF- interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a l...
T6961 PX-478 PX-478 2HCl HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
PX-478 is a HIF- inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...
T67836 AT-533 HSP , HSV
AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i...
T1939 DMOG Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T4381 Lificiguat YC-1 Others , Guanylate cyclase , HIF
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T2309 Ganetespib STA-9090 Apoptosis , HSP , HIF
Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T124358 Deferoxamine Deferoxamine B,Desferrioxamine B Apoptosis , Antioxidant , HIF , Autophagy
Deferoxamine(Desferrioxamine B) is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may imp...
T2283 PX-12 IV-2,PX12 Thioredoxin
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF- and vascular endothelial growth factor (VEGF) and inhibits tumor gr...
T0153 Oltipraz NSC 347901,RP 35972 HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T24148 HPCG
HPCG is an inhibitor of HIF- prolyl hydroxylase.
T6804 Chetomin Chaetomin,NSC289491,BRN0077366 Apoptosis , HSP , HIF
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF- and HIF-2α to p300 at low nanomolar concentrations.
T60398 Dimethyl-bisphenol A
Dimethyl-bisphenol A (DMBPA) is the potent inhibitor of HIF-. Dimethyl-Bisphenol A promotes degradation of HIF- protein by dissociating Hsp90 from HIF-. Dimethyl-bisphenol A can decrease the expression of Vegfa mRN...
T70788 KST012174 HCl
KST012174 is a HIF- inhibitor. KST012174 involves in the HIF-/p300 protein−protein interaction.
T27866 LXY6090 LXY 6090,LXY-6090
LXY6090 is a HIF-1 inhibitor. LXY6090 inhibited the activity of HIF-1 and downregulated the protein level of HIF- in breast cancer cells. LXY6090 showed in vivo anticancer efficacy by decreasing the HIF- expression i...
T23988 DHPCG
DHPCG is an inhibitor of HIF- prolyl hydroxylase.
T82595 DEALA-Hyp-YIPD
DEALA-Hyp-YIPD, an HIF- peptide inhibitor, impedes the VHL/HIF- interaction with an half-maximal inhibitory concentration (IC50) of 0.91 μM and a dissociation constant (Kd) of 180 nM [1].
T68718 103D5R
103D5R is a novel selective inhibitor of hif-, markedly decreasing hif- protein levels induced by hypoxia or cobaltous ions in a dose- and time-dependent manner
T75943 TAT-cyclo-CLLFVY TFA
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor specifically targeting HIF-1 heterodimerization to mitigate hypoxia signaling within cancer cells. It effectively disrupts the protein-protein interaction between HIF-...
TP2046 TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi...
T10258 AFP464 free base NSC710464 free base HIF
AFP464 (NSC710464) free base is an active HIF- inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
T74530 GEM-5
GEM-5, a gemcitabine-based conjugate incorporating a HIF- inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF- expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and c...
T60413 HIF-IN-1 HIF
HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF- protein aggregation.
T15234 ENMD-1198 IRC 110160,ENMD-119,ENMD 1198 HIF , STAT
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF- and STAT3 in human HCC cells.
T63035 Izilendustat hydrochloride
Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase that stabilizes hypoxia-inducible factor-1 alpha (HIF-) and hypoxia-inducible factor-2 (HIF-2). Potential for HIF--related diseases (including ...
T61442 HIF-1/2α-IN-1
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea...
T79720 VHL-IN-1 HIF/HIF Prolyl-Hydroxylase
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF- and enhances its transcriptional activity. It shows promise for appli...
T71116 MPT0B098
MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values r...
T26573 AG311 AG 311,AG-311
AG311 is an inhibitor of complex I and hypoxia-induced HIF- stabilization. In vitro, AG311 induces rapid necrosis in numerous cancer cell lines. Within minutes, exposure to AG311 also results in mitochondrial depolariz...

Compounds

HIF--IN-2
T61349
Synonym:
Target: HIF
LW6
T3494
Synonym: HIF- inhibitor,CAY10585,LW8
Target: Apoptosis, Dehydrogenase, HIF/HIF Prolyl-Hydroxylase, HIF
FM19G11
T36711
Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor
Target: HIF
1,4-DPCA
T21653
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
HIF--IN-6
T82198
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
HIF--IN-4
T60524
Synonym:
Target:
HIF--IN-5
T60532
Synonym:
Target:
HIF--IN-3
T61161
Synonym:
Target:
HIF- inhibitor-1
T71661
Synonym:
Target:
HIF--IN-2 hydrochloride
T78123
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Allopurinol
T0692
Synonym: Zyloric,Zyloprim,Lopurin
Target: ROS, Xanthine Oxidase
HS-1793
T8973
Synonym:
Target: Others
Indacaterol acetate
T71659
Synonym:
Target:
Allopurinol Sodium
T6376
Synonym: Allopurinol sodium salt,Sodium allopurinol
Target: ROS
Acriflavine Hydrochloride
T19832
Synonym: Acriflavine HCl
Target: HIF
ZINC13466751
T13398
Synonym:
Target: HIF
GN44028
T15396
Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Target: HIF
HIF-1 inhibitor-4
T67767
Synonym: HIF-1 inhibitor-4
Target: HIF
IDF-11774
T5537
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
TC-S 7009
T17009
Synonym:
Target: HIF
IR-780 Iodide
T20974
Synonym: IR 780 iodide
Target: Others
Deferoxamine Mesylate
T1637
Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM
Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy
VH032
T29106
Synonym: VH-032,VH 032
Target: Ligand for E3 Ligase
PX-478
T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
AT-533
T67836
Synonym:
Target: HSP, HSV
DMOG
T1939
Synonym: Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
Lificiguat
T4381
Synonym: YC-1
Target: Others, Guanylate cyclase, HIF
Ganetespib
T2309
Synonym: STA-9090
Target: Apoptosis, HSP, HIF
Deferoxamine
T124358
Synonym: Deferoxamine B,Desferrioxamine B
Target: Apoptosis, Antioxidant, HIF, Autophagy
PX-12
T2283
Synonym: IV-2,PX12
Target: Thioredoxin
Oltipraz
T0153
Synonym: NSC 347901,RP 35972
Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF
HPCG
T24148
Synonym:
Target:
Chetomin
T6804
Synonym: Chaetomin,NSC289491,BRN0077366
Target: Apoptosis, HSP, HIF
Dimethyl-bisphenol A
T60398
Synonym:
Target:
KST012174 HCl
T70788
Synonym:
Target:
LXY6090
T27866
Synonym: LXY 6090,LXY-6090
Target:
DHPCG
T23988
Synonym:
Target:
DEALA-Hyp-YIPD
T82595
Synonym:
Target:
103D5R
T68718
Synonym:
Target:
TAT-cyclo-CLLFVY TFA
T75943
Synonym:
Target:
TAT-cyclo-CLLFVY
TP2046
Synonym:
Target:
AFP464 free base
T10258
Synonym: NSC710464 free base
Target: HIF
GEM-5
T74530
Synonym:
Target:
HIF-IN-1
T60413
Synonym:
Target: HIF
ENMD-1198
T15234
Synonym: IRC 110160,ENMD-119,ENMD 1198
Target: HIF, STAT
Izilendustat hydrochloride
T63035
Synonym:
Target:
HIF-1/2α-IN-1
T61442
Synonym:
Target:
VHL-IN-1
T79720
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
MPT0B098
T71116
Synonym:
Target:
AG311
T26573
Synonym: AG 311,AG-311
Target:
1 2
カタログ番号 製品名 別名 ターゲット
T3860 Isoliquiritin apioside MMP , p38 MAPK , NF-κB
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T1123 Camptothecin NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
TN1480 Cephaeline Virus Protease , Influenza Virus , HIF
Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-± and disturbing intracellular redox homeostasis.
T5740 25(R,S)-Ruscogenin (25RS)-Ruscogenin Others , HIF
25(R,S)-Ruscogenin is a natual product.
T6S0071 Fraxinellone HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...
T3S2344 β,β-Dimethylacrylshikonin Dimethylacrylshikonin,β, β-Dimethylacrylshikonin ERK , HIF/HIF Prolyl-Hydroxylase
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...
T3816 Velutin NF-κB , HIF/HIF Prolyl-Hydroxylase
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...
T75487 7-Hydroxyneolamellarin A
7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor- (HIF-). It effectively reduces the accumulation of HIF- protein and suppresses ...
T36749 Herboxidiene
Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin...
T36439 Gramicidin A Antibacterial , HIF , Parasite
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-01709 HIF-1 alpha Protein, Human, Recombinant (His) Human E. coli
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (...
TMPY-00585 Annexin A8 Protein, Human, Recombinant (His) Human E. coli
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA...
TMPY-01576 Artemin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored...
カタログ番号 製品名
L8500 HIF-1 Signaling Pathway Compound Library

1336 compounds
A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;