keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Histatin 5 acetate inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 41,000 | |||
5 mg | 在庫あり | ¥ 102,000 | |||
10 mg | 在庫あり | ¥ 150,000 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 319,000 | |||
100 mg | 在庫あり | ¥ 431,500 |
説明 | Histatin 5 acetate inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. |
ターゲット&IC50 | MMP2:0.57 μM, MMP9:0.25 Μm |
In vitro | Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC50s, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 uM inhibits state 2 respiration. |
別名 | Histatin 5 acetate (115966-68-2 Free base) |
分子量 | 3096.35 |
分子式 | C135H199N51O35 |
CAS No. | TP1741L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Histatin 5 acetate TP1741L Proteases/Proteasome MMP Histatin 5 Acetate Histatin 5 acetate (115966-68-2 Free base) 115966-68-2 Free base 115966-68-2 Inhibitor inhibitor inhibit