Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 8,500 | |||
50 mg | 在庫あり | ¥ 10,500 | |||
100 mg | 在庫あり | ¥ 13,500 | |||
200 mg | 在庫あり | ¥ 21,000 | |||
500 mg | 在庫あり | ¥ 31,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. |
ターゲット&IC50 | mAChR (SHR-E):170.3 nM, mAChR (WKY-E):162.5 nM |
In vitro | Homatropine [14C]methylbromide administered rectally in rats achieved higher and quicker peak plasma concentrations compared to other routes. After 12 hours, 28% of the [14C] was excreted in the urine, with 56% remaining in the colon. Unlabeled homatropine methylbromide, delivered via a rectal suppository in anesthetized rats, rapidly blocked the effects of the vagus nerve on heart rate and of intravenous acetylcholine on blood pressure. A dose of 20 mg/kg homatropine increased the survival rate to 30% in rats poisoned with diazinon, with death occurring between 4 to 12 minutes, whereas a 10 mg/kg dose was ineffective in preventing mortality. |
In vivo | When combined with hexamethonium, 20 μM Homatropine yields only a dose ratio of 95.0 in guinea pig atria. In contrast, 20 μM Homatropine alone produces a dose ratio of 259 in guinea pig atria. |
別名 | Homatropine methobromide |
分子量 | 370.29 |
分子式 | C17H24BrNO3 |
CAS No. | 80-49-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (135.03 mM)
Ethanol: 10 mg/mL (27.0 mM)
H2O: 68 mg/mL (183.6 mM)
You can also refer to dose conversion for different animals. 詳細
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Homatropine Methylbromide 80-49-9 Neuroscience AChR Inhibitor Homatropine methobromide Muscarinic acetylcholine receptor mAChR inhibit inhibitor