Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 59,500 | |||
10 mg | 在庫あり | ¥ 89,000 | |||
25 mg | 在庫あり | ¥ 146,500 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,000 |
説明 | Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. |
In vitro | The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1] |
植物由来 |
分子量 | 430.49 |
分子式 | C24H30O7 |
CAS No. | 33676-00-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (232.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Hypophyllanthin 33676-00-5 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel Potassium Channel P-gp Inhibitor CD243 Pgp inhibit ABCB1 P-glycoprotein Cluster of differentiation 243 Multidrug resistance protein 1 MDR1 inhibitor